Schultz R J, Glaze D G, Motil K J, Armstrong D D, del Junco D J, Hubbard C R, Percy A K
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
Am J Dis Child. 1993 Jun;147(6):633-7. doi: 10.1001/archpedi.1993.02160300039018.
To define the growth pattern of girls with Rett syndrome with respect to height, weight, and fronto-occipital head circumference.
Longitudinal with irregular intervals between measurements.
Rett Syndrome Program Project at Baylor College of Medicine, Houston, Tex.
Ninety-six girls fulfilling criteria for Rett syndrome; comparison group with standard growth curves.
Consecutive entries into the Rett Syndrome Program Project.
None.
MEASUREMENTS/MAIN RESULTS: Height, weight, and fronto-occipital head circumference data were grouped into intervals. Group medians were then generated. Regression lines were fitted through the median points and plotted on standard growth charts. Deceleration of growth velocities began at age 3 months and persisted through age 18 years.
Early deceleration of head growth, followed by deceleration of weight and height measurements, appears to be a growth pattern characteristic of Rett syndrome. This pattern of growth may provide the earliest clinical indicator for the diagnosis of Rett syndrome.
确定患有雷特综合征女童在身高、体重及额枕部头围方面的生长模式。
测量间隔不规律的纵向研究。
德克萨斯州休斯顿贝勒医学院雷特综合征项目计划。
96名符合雷特综合征标准的女童；与标准生长曲线进行比较的对照组。
连续纳入雷特综合征项目计划。
无。
测量指标/主要结果：身高、体重及额枕部头围数据被分组。然后生成组中位数。通过中位数点拟合回归线并绘制在标准生长图表上。生长速度在3个月龄时开始减速，并持续至18岁。
头部生长早期减速，随后体重和身高测量减速，似乎是雷特综合征的生长模式特征。这种生长模式可能为雷特综合征的诊断提供最早的临床指标。
