African origin of GB virus C/hepatitis G virus.

作者信息

Tanaka Y, Mizokami M, Orito E, Ohba K, Kato T, Kondo Y, Mboudjeka I, Zekeng L, Kaptue L, Bikandou B, M'Pele P, Takehisa J, Hayami M, Suzuki Y, Gojobori T

机构信息

Second Department of Medicine, Nagoya City University Medical School, Kawasumi, Mizuho, Japan.

出版信息

FEBS Lett. 1998 Feb 20;423(2):143-8. doi: 10.1016/s0014-5793(98)00083-0.

Ninety-four GB virus C/hepatitis G virus (GBV-C/ HGV) RNA-positive serum samples were obtained from all over the world. We found that all 15 GBV-C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12-amino acid indel (i.e. insertion or deletion) in the non-structural protein (NS) 5A region. Phylogenetic analyses of the NS5A region, using GBV-A as an outgroup, showed that these 15 isolates had diverged from the common ancestor much earlier than the remaining isolates, indicating an African origin of GBV-C/HGV.