Itsubo M, Koike K, Toda G
Department of Internal Medicine 1, Jikei University School of Medicine.
Gan To Kagaku Ryoho. 1998 Feb;25 Suppl 1:84-9.
The therapeutic effectiveness of transcatheter arterial embolization (TAE) with intraarterial infusion of SMANCS/lipiodol mixture was retrospectively compared to TAE with intraarterial infusion of epirubicin/lipiodol mixture in initial treatment of 54 patients with unresected hepatocellular carcinoma. The therapeutic effects were evaluated by the rate of tumor necrosis after the initial procedure and the cumulative survival rate. Eighteen patients were treated with SMANCS, and 36 patients were treated with epirubicin. There was no significant difference in patient background between the two groups; the hepatic functional reserve was not seriously disturbed in most of the patients, and multiple hepatic lesions were seen in half the patients. Complete tumor necrosis assessed by the imaging of dynamic CT one month after TAE was seen in approximately 40% of the cases in each group. Local recurrence was seen in half the patients after assessment of complete tumor necrosis within one year in both groups. There was no significant difference in survival period. There was also no significant difference of the frequency and degree of the side effects. In conclusion, no distinct difference of outcome was found in the two groups in this comparative study. Further studies in many cases over a longer period will be needed to elucidate the effects of SMANCS in TAE.
回顾性比较经动脉内注入丝裂霉素超液化碘油（SMANCS）/碘油混合物的经导管动脉栓塞术（TAE）与经动脉内注入表柔比星/碘油混合物的TAE对54例无法切除的肝细胞癌患者进行初始治疗的疗效。通过初始治疗后的肿瘤坏死率和累积生存率评估治疗效果。18例患者接受丝裂霉素治疗，36例患者接受表柔比星治疗。两组患者的背景无显著差异；大多数患者的肝功能储备未受到严重干扰，半数患者可见多发肝病变。TAE术后1个月通过动态CT成像评估，每组约40%的病例出现完全肿瘤坏死。两组患者在1年内评估完全肿瘤坏死后，半数患者出现局部复发。生存期无显著差异。副作用的频率和程度也无显著差异。总之，在这项比较研究中，两组的结果没有明显差异。需要在更多病例上进行更长时间的进一步研究，以阐明丝裂霉素在TAE中的作用。
