Tan C T, Herman P
Laboratoire d'Otologie Expérimentale, Faculté Lariboisière-St-Louis, Paris, France.
Auris Nasus Larynx. 1998 Jan;25(1):25-32. doi: 10.1016/s0385-8146(97)10026-8.
Otitis media with effusion is characterized by the presence of an inflammatory cellular infiltrate of the submucosa and a poor ventilation of the middle ear. This result in hypersecretion of mucus and alteration of the mucociliary clearance, which produce accumulation of fluid and cellular debris in the middle ear. The aim of this work was to investigate whether inflammatory mediators such as prostaglandins and oxygen metabolites modulate the absorptive function of the middle ear epithelium. The data we present demonstrated that: (i) among prostanoids, only prostaglandin E2 modulated the rate of sodium transport; (ii) oxidants had a stimulatory effect on ion transport; (iii) the role of reactive oxygen species was mediated by prostaglandin E2. This process might be involved in the impairment of the mucociliary clearance.
分泌性中耳炎的特征是黏膜下层存在炎性细胞浸润以及中耳通气不良。这会导致黏液分泌过多和黏液纤毛清除功能改变，进而使中耳内出现液体和细胞碎片积聚。本研究的目的是调查前列腺素和氧代谢产物等炎性介质是否调节中耳上皮的吸收功能。我们展示的数据表明：（i）在前列腺素类物质中，只有前列腺素E2调节钠转运速率；（ii）氧化剂对离子转运有刺激作用；（iii）活性氧物质的作用是由前列腺素E2介导的。这一过程可能与黏液纤毛清除功能受损有关。
