Dyck R F, Tan L
Department of Medicine, College of Medicine, University of Saskatchewan, Saskatoon.
Clin Invest Med. 1998 Feb;21(1):33-8.
To determine the rates, causes and outcomes of non-diabetic end-stage renal disease (ESRD) among aboriginal and non-aboriginal people in Saskatchewan.
Retrospective population-based study using data from the Canadian Organ Replacement Register.
Saskatchewan.
All patients with non-diabetic ESRD diagnosed between Jan. 1, 1981, and Dec. 31, 1990.
Age- and sex-specific as well as age-adjusted incidence rates of non-diabetic ESRD among aboriginal and non-aboriginal people in Saskatchewan, causes of non-diabetic ESRD, mortality rates, causes of death and renal transplantation rates.
The 10-year incidence rates of non-diabetic ESRD were higher in all age groups among aboriginal people than among non-aboriginal people. The overall risk ratio for aboriginal people was 2.56. Aboriginal people experienced non-diabetic ESRD at an earlier age and were twice as likely to have a form of glomerulonephritis as a cause. Crude mortality rates, causes of death and transplantation rates were similar in the 2 populations, although we were unable to adjust these for differences in age.
Although diabetes is the most common cause of ESRD among aboriginal people in Saskatchewan, this population also experiences an excessive burden of non-diabetic ESRD, which is largely explained by a higher rate of glomerulonephritis.
确定萨斯喀彻温省原住民和非原住民中非糖尿病终末期肾病（ESRD）的发病率、病因及转归。
基于加拿大器官移植登记处数据的回顾性人群研究。
萨斯喀彻温省。
1981年1月1日至1990年12月31日期间确诊的所有非糖尿病ESRD患者。
萨斯喀彻温省原住民和非原住民中非糖尿病ESRD的年龄和性别特异性发病率以及年龄调整发病率、非糖尿病ESRD的病因、死亡率、死亡原因和肾移植率。
原住民各年龄组中非糖尿病ESRD的10年发病率均高于非原住民。原住民的总体风险比为2.56。原住民患非糖尿病ESRD的年龄更早，患某种肾小球肾炎作为病因的可能性是后者的两倍。尽管我们无法对年龄差异进行调整，但这两个人群的粗死亡率、死亡原因和移植率相似。
虽然糖尿病是萨斯喀彻温省原住民ESRD最常见的病因，但该人群也承受着非糖尿病ESRD的过重负担，这在很大程度上是由较高的肾小球肾炎发病率所致。
