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孕期治疗乳腺癌。哪些药物可以安全使用?

Treating breast cancer during pregnancy. What can be taken safely?

作者信息

Espié M, Cuvier C

机构信息

Centre des Maladies du Sein, Oncologie Médicale, Hôpital St Louis, Paris, France.

出版信息

Drug Saf. 1998 Feb;18(2):135-42. doi: 10.2165/00002018-199818020-00005.

Abstract

The occurrence of breast cancer during pregnancy is a rare clinical situation. However, if it is diagnosed, a multidisciplinary approach involving an obstetrician, a medical oncologist and a surgeon is needed. In this situation, breast cancer should be treated according to the same principles applied in nonpregnant patients. Termination of pregnancy does not improve survival. Decisions regarding abortion should be based on the desires of the patient and on therapeutic necessities. If required, surgery is always possible, but radiation therapy should be avoided because of the risk of fetal toxicity. Antineoplastic drug therapy, if indicated, is possible after the first trimester.

摘要

妊娠期间发生乳腺癌是一种罕见的临床情况。然而,如果确诊,需要产科医生、肿瘤内科医生和外科医生采取多学科方法。在这种情况下,乳腺癌应按照适用于非妊娠患者的相同原则进行治疗。终止妊娠并不能提高生存率。关于堕胎的决定应基于患者的意愿和治疗需要。如有必要,手术总是可行的,但由于存在胎儿毒性风险,应避免放疗。如果有指征,在孕早期过后可进行抗肿瘤药物治疗。

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