The effect on cortical mirror foci produced by ouabain of gamma-aminobutyric acid, dopamine and haloperidol injected into the rabbit caudate nucleus.

Epileptiform activity is inhibited by injection of dopamine, and potentiated by injections of haloperidol into the caudate nucleus. gamma-Aminobutyric acid (GABA) initially potentiates, and shortly after that inhibits the epileptoform activity in the cortex. The authors discuss a possibility of combined treatment of seizure states with dopamine-mimetic and GABA-mimetic agents.