Misterka S, Paluch D, Zywicka B, Staniszewska-Kuś J, Pobiedzińska J
Zakład Chirurgii Eksperymentalnej i Badania Biomateriałów, Katedra Chirurgii Urazowej Akademii Medycznej, Wrocławiu.
Polim Med. 1998;28(1-2):15-24.
Evaluation of biomaterials with the help of routine methods not always allow full and explicit stating of their toxicity. That is why we still seek new methods of evaluation of biocompatibility on the cellular level. Usage of changes in activity of interleukin after biomaterials implantation creates such a possibility. The aim of this work as use of changes in activity of cytokines IL-1 beta and cytokines IL-6 for evaluation of biocompatibility of chosen medical materials. The tests were made on mice to whom polyester and aramid fibres as well as discs of rubber drains were implanted into the peritoneal cavity. Evaluation of the changes of the level of interleukin-1 beta and interleukin-6 was made in the fluid from the peritoneal cavity 3, 7, 14 and 21 days after implantation. Introductory tests of changes in the level of IL-1 beta and IL-6 after implantation of biomaterials with different degree of biocompatibility allow to assume that testing their activity may be useful in evaluation of their toxic effect.
