Li B, Jin F, Yang L
Department of Obstetrics, Hospital of Obstetrics and Gynecology, Shanghai Medical University, Shanghai 200011, China.
Zhonghua Fu Chan Ke Za Zhi. 2000 Mar;35(3):166-8.
To evaluate the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) before and after conservative laparoscopic surgery in patients with endometriosis.
The TNF-alpha and IL-6 levels in serum and peritoneal fluid of 20 endometriotic patients and 10 control patients were determined by radioimmunoassay.
Significant parallel relationship existed between the stage of endometriosis and the TNF-alpha and IL-6 levels in serum and peritoneal fluid in endometriosis patients (r values: serum: 0.80, 0.52; peritoneal fluid: 0.79, 0.49, P < 0.05). After clearance of endometriosis foci with laparoscopic conservative surgery, the TNF-alpha and IL-6 levels decreased significantly.
Measuring TNF-alpha and IL-6 level may have important value in postoperative follow-up, surveillance and evaluation of the effectiveness of surgery.
评估子宫内膜异位症患者保守性腹腔镜手术前后肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）的水平。
采用放射免疫分析法测定20例子宫内膜异位症患者和10例对照患者血清及腹腔液中TNF-α和IL-6的水平。
子宫内膜异位症患者的子宫内膜异位症分期与血清及腹腔液中TNF-α和IL-6水平之间存在显著的平行关系（r值：血清：0.80，0.52；腹腔液：0.79，0.49，P<0.05）。经腹腔镜保守手术清除子宫内膜异位症病灶后，TNF-α和IL-6水平显著下降。
检测TNF-α和IL-6水平对术后随访、监测及评估手术疗效可能具有重要价值。
