Suda T, Sugimura S, Hattori Y, Sugimura H, Kobayashi Y, Hoshino R
Department of Thoracic Surgery, Fujita Health University, Aichi, Japan.
Jpn J Thorac Cardiovasc Surg. 1998 Jan;46(1):115-20. doi: 10.1007/BF03217734.
During the period from May, 1995 to August, 1996, three patients with Stage III or IVa invasive thymoma received chemotherapy consisting of cisplatin, doxorubicin and methylprednisolone (1000 mg on days 1 through 5, and 500 mg on days 6 and 7). The first case, a 55-year-old woman, who underwent extended thymectomy 7 years ago, was found to have a recurrent tumor in the left pleural cavity. The second case, a 38-year-old man, who had first operation 3 years ago, developed recurrent tumor in the right pleural cavity. These two patients were treated with the above regimen as the primary mode of therapy. The third case, a 61-year-old woman, had a thymoma with direct invasion to right upper lobe. The same chemotherapy regimen was employed as the induction chemotherapy. All patients showed a major response to treatment with only a small amount of tumor remaining. The effectiveness of chemotherapy in the treatment of malignant tumors has been recently reported to be at least partly due to induction of apoptosis. Steroids are known to induce apoptosis in normal thymic cells, and thus steroid in chemotherapy regimen against invasive thymoma may enhance the effect of anti-cancer drugs through the induction of apoptosis.
在1995年5月至1996年8月期间，3例III期或IVa期浸润性胸腺瘤患者接受了由顺铂、阿霉素和甲基强的松龙组成的化疗（第1至5天为1000毫克，第6和7天为500毫克）。第一例是一名55岁女性，7年前接受了扩大胸腺切除术，发现左胸腔有复发性肿瘤。第二例是一名38岁男性，3年前首次手术，右胸腔出现复发性肿瘤。这两名患者接受上述方案作为主要治疗方式。第三例是一名61岁女性，患有直接侵犯右上叶的胸腺瘤。同样的化疗方案用作诱导化疗。所有患者对治疗均有显著反应，仅残留少量肿瘤。最近报道化疗对恶性肿瘤的疗效至少部分归因于诱导细胞凋亡。已知类固醇可诱导正常胸腺细胞凋亡，因此针对浸润性胸腺瘤的化疗方案中的类固醇可能通过诱导细胞凋亡增强抗癌药物的效果。
