Johnson M R, Marazziti D, Brawman-Mintzer O, Emmanuel N P, Ware M R, Morton W A, Rossi A, Cassano G B, Lydiard R B
Department of Psychiatry, Medical University of South Carolina, Charleston 29451, USA.
Biol Psychiatry. 1998 Feb 15;43(4):306-9. doi: 10.1016/S0006-3223(97)00390-9.
Peripheral benzodiazepine receptors (PBRs) are involved in regulating stress responses. Abnormally low numbers of platelet PBRs have been found in patients with panic disorder, posttraumatic stress disorder, and generalized anxiety disorder, but not in patients with obsessive-compulsive disorder (OCD) or major depressive disorder (MDD). The purpose of this study was to evaluate the PBR density on platelets from patients with generalized social phobia (GSP).
The density (Bmax) and dissociation constant (Kd) of platelet PBRs was determined for 53 medication-free patients with GSP and an equal number of control subjects (NC).
The GSP group was found to have a significantly lower PBR Bmax than the NC group (GSP = 2764 +/- 1242 vs. NC = 4327 +/- 1850 fmol/mg protein, df = 1,100, F = 22.7, p = .00001).
GSP shares this PBR abnormality with some other anxiety disorders but not with OCD or MDD. PBRs may play a role in the pathophysiology of some anxiety disorders.
外周苯二氮䓬受体（PBRs）参与调节应激反应。在惊恐障碍、创伤后应激障碍和广泛性焦虑症患者中发现血小板PBRs数量异常低，但在强迫症（OCD）或重度抑郁症（MDD）患者中未发现。本研究的目的是评估广泛性社交恐惧症（GSP）患者血小板上的PBR密度。
测定了53名未服用药物的GSP患者和同等数量的对照受试者（NC）的血小板PBRs密度（Bmax）和解离常数（Kd）。
发现GSP组的PBR Bmax显著低于NC组（GSP = 2764 +/- 1242对NC = 4327 +/- 1850 fmol/mg蛋白，自由度 = 1,100，F = 22.7，p = 0.00001）。
GSP与其他一些焦虑症有这种PBR异常，但与OCD或MDD没有。PBRs可能在某些焦虑症的病理生理学中起作用。
