Weizman A, Burgin R, Harel Y, Karp L, Gavish M
Geha Psychiatric Hospital, Petah Tiqva, Israel.
J Affect Disord. 1995 Apr 4;33(4):257-61. doi: 10.1016/0165-0327(94)00098-t.
The peripheral-type benzodiazepine receptor (PBR) plays a major role in steroidogenesis. This receptor is sensitive to endocrine changes and stress. Antidepressants have been demonstrated to modulate adrenal and hepatic PBR in rats. To evaluate the relationship between depression and PBR, we measured platelet PBR in untreated depressed patients (n = 14) in comparison to normal controls (n = 13). Platelet PBR density (Bmax) and the dissociation constant (kd) of the receptor did not differ in the patients when compared with normal controls. Furthermore, no correlation was found between Bmax values and the severity of the depression (as measured by the Hamilton Depression Rating Scale and Beck Depression Inventory) as well as with the severity of the anxiety (as measured by the Hamilton Anxiety Rating Scale). It seems that major depression, in contrast to stress and some anxiety disorders, is not associated with alteration of PBR.
外周型苯二氮䓬受体（PBR）在类固醇生成中起主要作用。该受体对内分泌变化和应激敏感。已证明抗抑郁药可调节大鼠肾上腺和肝脏中的PBR。为了评估抑郁症与PBR之间的关系，我们测量了未经治疗的抑郁症患者（n = 14）与正常对照者（n = 13）的血小板PBR。与正常对照者相比，患者的血小板PBR密度（Bmax）和受体解离常数（kd）没有差异。此外，未发现Bmax值与抑郁症严重程度（通过汉密尔顿抑郁量表和贝克抑郁量表测量）以及焦虑严重程度（通过汉密尔顿焦虑量表测量）之间存在相关性。与应激和某些焦虑症相反，重度抑郁症似乎与PBR改变无关。
