Saul'skaya N B, Marsden C A
Laboratory for the Physiology of Higher Nervous Activity, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Neurosci Behav Physiol. 1998 Jan-Feb;28(1):60-4. doi: 10.1007/BF02461913.
Studies on Lister rats, using intracerebral dialysis in behaving animals combined with high-performance liquid chromatography with electrochemical detection, showed that the development and realization of an emotional conditioned response were accompanied by increases in the gamma-aminobutyric acid (GABA) levels in the extracellular space of the medial part of the nucleus accumbens. Regression analysis demonstrated that measures of investigative behavior (horizontal movements, rearings, and sniffing and grooming times) during quenching of the emotional conditioned response (but not on presentation of the experimental chamber to control rats) correlated with individual changes in the extracellular GABA levels in the nucleus accumbens. Thus, this is the first report of in vivo recording of changes in GABA levels in the extracellular space of the brain during realization of normal behavior.
对利斯特大鼠的研究，采用在行为动物中进行脑内透析并结合高效液相色谱电化学检测的方法，结果显示，情绪条件反应的形成与实现伴随着伏隔核内侧部分细胞外空间中γ-氨基丁酸（GABA）水平的升高。回归分析表明，在情绪条件反应消退期间（而非将实验箱呈现给对照大鼠时）的探究行为测量指标（水平运动、竖毛以及嗅探和梳理时间）与伏隔核细胞外GABA水平的个体变化相关。因此，这是关于正常行为实现过程中大脑细胞外空间GABA水平变化的体内记录的首篇报道。
