Balster R L, Kilbey M M, Ellinwood E H
Psychopharmacologia. 1976 Apr 15;46(3):229-33. doi: 10.1007/BF00421107.
A procedure for studing intravenous drug self-administration in the cat is described. Ten cats were given 24-h access to methamphetamine reinforcement (0.04 mg/kg/inj). The subjects maintained a significantly higher response rate for drug reinforcement than for saline. The pattern of self-administration over days alternated between periods of high and low drug intake. Six additional cats were used to study the effect of dose per injection on methamphetamine self-administration under conditions of limited access. When methamphetamine was subtituted at various doses per infusion in animals maintained on cocaine reinforcement, response rate was shown to be an inverted U-shaped function of dose. These studies demonstrate that methamphetamine is a reinforcer in the cat and its patterns of intake under conditions of 24-h and limited access resemble other species.
本文描述了一种研究猫静脉注射药物自我给药的方法。十只猫被给予24小时获取甲基苯丙胺强化物（0.04毫克/千克/注射）的机会。与生理盐水相比，这些实验对象对药物强化物的反应率显著更高。随着时间推移，自我给药模式在高药物摄入量和低药物摄入量之间交替。另外六只猫用于在有限获取条件下研究每次注射剂量对甲基苯丙胺自我给药的影响。当在维持可卡因强化的动物中以不同剂量每次输注替代甲基苯丙胺时，反应率显示为剂量的倒U形函数。这些研究表明甲基苯丙胺在猫中是一种强化物，其在24小时和有限获取条件下的摄入模式与其他物种相似。
