Waser P G, Martin A, Heer-Carcano L
Psychopharmacologia. 1976 Apr 15;46(3):249-54. doi: 10.1007/BF00421110.
The course of active avoidance learning of rats in a symmetrical Y-maze under the influence of 1, 3, and 9 mg/kg of delta 9-THC i.p., and 5, 20, and mug/kg of LSD was investigated. Delta-THC in a dosage of 1 mg/kg had no effect on avoidance learning. Three to a lesser extent 9 mg/kg produced more rapid learning with a significantly better performance. Learning under delta 9-THC proved to be state-dependent. The withdrawal of delta 9-THC caused a decrease in the avoidance rate, which was dependent on the dosage. Upon renewal of the THC doses, the animals reattained their earlier preformance. In the course of the experiment there was rapid tolerance development, especially of the sedative properties of THC. LSD retarded the rate of acquisition of the active avoidance response. Whereas the control animals displayed over 80% successful active avoidance from the 14th session onwards, this was achieved by the LSD groups only after the 20th session. However, in contrast to the control group the LSD animals were able to increase their avoidance rate to over 90%, and this was maintained to the end of the experiment (a total of 24 sessions with LSD). The sudden withdrawal of LSD produced a fall in avoidance rate, which was dependent on the pervious training dosage; as with delta 9-THC state-dependent learning can also be assumed for LSD.
研究了腹腔注射1、3和9毫克/千克的δ9-四氢大麻酚（delta 9-THC）以及5、20和微克/千克的麦角酸二乙酰胺（LSD）对大鼠在对称Y型迷宫中主动回避学习过程的影响。1毫克/千克剂量的δ-THC对回避学习没有影响。3毫克/千克在较小程度上，9毫克/千克能使学习更快，表现明显更好。在δ9-THC作用下的学习被证明是状态依赖的。停用δ9-THC会导致回避率下降，这取决于剂量。重新给予THC剂量后，动物恢复到之前的表现。在实验过程中，耐受性迅速发展，尤其是对THC的镇静特性。LSD延缓了主动回避反应的习得速度。对照组动物从第14次训练开始主动回避成功率超过80%，而LSD组直到第20次训练后才达到这一水平。然而，与对照组不同的是，LSD处理的动物能够将回避率提高到90%以上，并维持到实验结束（LSD组共进行24次训练）。突然停用LSD会导致回避率下降，这取决于之前的训练剂量；与δ9-THC一样，LSD也可假定存在状态依赖学习。
