Bueno O F, Carlini E A, Finkelfarb E, Suzuki J S
Psychopharmacologia. 1976 Apr 15;46(3):235-43. doi: 10.1007/BF00421108.
Three groups of rats (A, B, C) were trained in a T-maze discriminate between drug-and control solution-induced internal discriminative stimuli. The drugs used to induce discriminative stimuli were: delta 9-THC, 5.0 mg/kg (Group A); ethanol, 1.2 g/kg (Group B), and amphetamine, 1.0 mg/kg(Group C). After discrimination acquisition several drugs were tested for generalization in each group. Group A was tested with delta 8-THC, CBD, CBN, ethanol, pentobarbital,chlorpromazine, amphetamine, and apomorphine; only delta8-THC and CBN induced delta9-THC-like responses. Group B was tested with delta 9-THC, delta 8-THC, CBD, CBN, pentobarbital, and amphetamine; pentobarbital induced ethanol-like response. Group C was tested with delta 9-THC, apomorphine, and ethanol; delta 9-THC and apomorphine elicited amphetamine-like responses.
将三组大鼠（A组、B组、C组）置于T型迷宫中进行训练，以区分药物和对照溶液诱发的内感受性辨别刺激。用于诱发辨别刺激的药物分别为：δ9-四氢大麻酚，5.0毫克/千克（A组）；乙醇，1.2克/千克（B组）；苯丙胺，1.0毫克/千克（C组）。在辨别训练完成后，对每组大鼠测试几种药物的泛化情况。A组用δ8-四氢大麻酚、大麻二酚、大麻酚、乙醇、戊巴比妥、氯丙嗪、苯丙胺和阿扑吗啡进行测试；只有δ8-四氢大麻酚和大麻酚诱发了类似δ9-四氢大麻酚的反应。B组用δ9-四氢大麻酚、δ8-四氢大麻酚、大麻二酚、大麻酚、戊巴比妥和苯丙胺进行测试；戊巴比妥诱发了类似乙醇的反应。C组用δ9-四氢大麻酚、阿扑吗啡和乙醇进行测试；δ9-四氢大麻酚和阿扑吗啡引发了类似苯丙胺的反应。
