Fuster V
Cardiovascular Institute, Mount Sinai Medical Center, New York, NY 10029-6574, USA.
Arch Mal Coeur Vaiss. 1997 Nov;90 Spec No 6:41-7.
Our knowledge of the pathophysiology of coronary atherosclerosis has remarkably changed in the last few years. The types of atherosclerotic lesions, the mechanisms of progression of coronary atherosclerosis with plaque instability and disruption, and the subsequent thrombotic phenomenon leading to acute coronary syndromes are now better understood. Therapeutic strategies leading to atherosclerotic lesion stabilization and even regression, as well as new antithrombotic strategies to alleviate or prevent the thrombotic complications are being pursued. This review focuses on the coronary unstable atherosclerotic plaque and complicating thrombosis.
在过去几年中，我们对冠状动脉粥样硬化病理生理学的认识发生了显著变化。现在，我们对动脉粥样硬化病变的类型、冠状动脉粥样硬化伴斑块不稳定和破裂的进展机制，以及随后导致急性冠状动脉综合征的血栓形成现象有了更好的理解。目前正在探索能够使动脉粥样硬化病变稳定甚至逆转的治疗策略，以及减轻或预防血栓形成并发症的新抗栓策略。本综述重点关注冠状动脉不稳定粥样硬化斑块及并发的血栓形成。
