Ohno T, Yoshida F, Ichikawa Y, Matsuo S, Hotta N, Terada M, Tanaka S, Yamashita K, Namikawa T, Kitoh J
Department of Parasitology, Hamamatsu University School of Medicine, Japan.
Life Sci. 1998;62(11):995-1006. doi: 10.1016/s0024-3205(98)00020-4.
The EDS (early-onset diabetes in suncus) colony has been developed as a new closed breeding colony of the musk shrew (Suncus murinus, Insectivora) exhibiting a high incidence of spontaneous diabetes mellitus. We investigated the characteristic features of diabetic shrews in this colony. All diabetic shrews are characterized by glycosuria (Tes-tape value > or = 3+), hyperglycemia (23.3 +/- 0.8 mmol/l) and polyuria, and they were affected by the age of 3 months. Cumulative incidence (64.1% in males and 27.8% in females) was kept intact after the age of 3 months. The growth pattern of diabetic shrews was similar to that of non-diabetic shrews, and obesity was not consistent in diabetic shrews. The intraperioneal glucose tolerance test revealed both impaired glucose tolerance and impaired insulin secretion in diabetic shrews. Insulin sensitivity of diabetic shrews decreased in the intraperioneal insulin tolerance test. Neither severe hypertrophy nor lymphocytic infiltration was observed in pancreatic islets of diabetic shrews. These facts suggested that diabetic shrews in the EDS colony should be classified as early-onset non-insulin dependent diabetes mellitus (NIDDM) without obesity. Early-onset of severe hyperglycemia with impaired glucose tolerance is a distinctive character compared with other non-obese NIDDM models in rodents. We concluded that the diabetic shrews in the EDS colony are a new animal model of human NIDDM without obesity.
已培育出 EDS（太阳麝鼩早发性糖尿病）群体，作为麝鼩（太阳麝鼩，食虫目）的一个新的封闭繁殖群体，该群体自发性糖尿病发病率很高。我们研究了这个群体中糖尿病麝鼩的特征。所有糖尿病麝鼩的特征为糖尿（尿糖试纸值≥3+）、高血糖（23.3±0.8 mmol/l）和多尿，且在 3 个月龄时就会出现这些症状。3 个月龄后累积发病率保持不变（雄性为 64.1%，雌性为 27.8%）。糖尿病麝鼩的生长模式与非糖尿病麝鼩相似，且糖尿病麝鼩并不都肥胖。腹腔内葡萄糖耐量试验显示糖尿病麝鼩存在葡萄糖耐量受损和胰岛素分泌受损的情况。在腹腔内胰岛素耐量试验中，糖尿病麝鼩的胰岛素敏感性降低。在糖尿病麝鼩的胰岛中未观察到严重肥大或淋巴细胞浸润。这些事实表明，EDS 群体中的糖尿病麝鼩应归类为早发性非胰岛素依赖型糖尿病（NIDDM）且不伴有肥胖。与啮齿动物中的其他非肥胖 NIDDM 模型相比，严重高血糖伴葡萄糖耐量受损的早发性是其一个显著特征。我们得出结论，EDS 群体中的糖尿病麝鼩是一种新的不伴有肥胖的人类 NIDDM 动物模型。
