Johns D P, Side E, Kendrick A H, Williams T J, Walters E H
Department of Respiratory Medicine, The Alfred Hospital and Monash University Medical School, Melbourne, Victoria, Australia.
Chest. 1998 Mar;113(3):774-9. doi: 10.1378/chest.113.3.774.
To investigate the effects of physiologic and mechanical aging on peak flowmeters.
Eight each of MiniWright (MW; Clement Clark; Harlow, UK), Personal-Best (PB; HealthScan Products; Cedar Grove, NJ), Vitalograph (V; Vitalograph Ltd; Buckingham, UK), and Breath-Taker (BT; Medical Development Australia; Melbourne, Australia) peak flowmeters were assessed for accuracy and repeatability before and after aging using a computer-driven syringe to deliver peak flows from 100 to 700 L/min. Four of each type of flowmeter were physiologically aged by normal subjects performing up to six peak flows daily for 1 year. The remaining four of each flowmeter were mechanically aged using an accelerated aging device to deliver 2,000 exponential waveforms with a peak flow of 600 L/min over a period of 3 h.
The V and BT flowmeters were linear and accurate over the range 100 to 700 L/min, while the PB overread at high flows. The MW was alinear throughout. The SD of the difference between readings before and after aging ranged from 8.6 to 40.6 L/min (mean, 9.2). Comparing the slopes of the relationship of actual against reference peak expiratory flow (PEF) showed that 16 flowmeters--5 BTs, 6 MWs, 4 PBs, and 1 V had no significant change in slope after aging. Mechanical aging caused a consistent underreading in PEF at high flow rates. Physiologic aging showed a more variable pattern both within and between flowmeter types. The MW was the most affected by physiologic aging, producing overestimates of PEF by as much as 100 L/min at 500 L/min.
We conclude that the effects of physiologic and mechanical aging are different, and that while mechanical aging may provide a guide to the effects of aging, studies using physiologic aging would be more appropriate.
研究生理老化和机械老化对峰值流量计的影响。
使用计算机驱动的注射器输送100至700升/分钟的峰值流量,对八台MiniWright(MW;克莱门特·克拉克公司;英国哈洛)、八台个人最佳(PB;健康扫描产品公司;美国新泽西州锡达格罗夫)、八台维托拉夫(V;维托拉夫有限公司;英国白金汉)和八台呼吸测试仪(BT;澳大利亚医学发展公司;澳大利亚墨尔本)峰值流量计在老化前后的准确性和可重复性进行评估。每种流量计中的四台通过正常受试者每天进行多达六次峰值流量测试,持续1年进行生理老化。每种流量计的其余四台使用加速老化装置在3小时内输送2000个峰值流量为600升/分钟的指数波形进行机械老化。
V型和BT型流量计在100至700升/分钟的范围内呈线性且准确,而PB型在高流量时读数偏高。MW型始终呈非线性。老化前后读数差异的标准差在8.6至40.6升/分钟之间(平均为9.2)。比较实际峰值呼气流量(PEF)与参考值之间关系的斜率表明,16台流量计——5台BT型、6台MW型、4台PB型和1台V型在老化后斜率无显著变化。机械老化导致高流量时PEF持续读数偏低。生理老化在流量计类型内部和类型之间表现出更具变化性的模式。MW型受生理老化影响最大,在500升/分钟时PEF高估多达100升/分钟。
我们得出结论,生理老化和机械老化的影响不同,虽然机械老化可能为老化影响提供一个指导,但使用生理老化的研究将更合适。