Thormann J, Schwarz F
Scand J Thorac Cardiovasc Surg. 1976;10(2):149-55. doi: 10.3109/14017437609167784.
Twelve arrhythmias that occurred in conjunction with surgery for congenital heart disease were studied in a group of 38 randomly selected patients. Halothane was used for anaesthesia and procaine-magnesium-aspartate solution for cardiac arrest. Registration and analysis of rhythm disturbances were carried out at 10 different time points, spaced narrowly in the intra- and early postoperative phases, then more widely up to the 96th hour of observation. Arrhythmic incidence per case and occurrence per case and phase are given, thereby also allowing an account of transient arrhythmias. The peak occurrence of intra-operative rhythm disturbances was found at about the time of aortic cross-clamping and release (ischaemia and halothane effect). A decline in arrhythmic incidence in the 1st-6th post-bypass hours was followed by a 2nd peak in the 6th-23rd postoperative hours (electrolyte and acid-base disturbances and/or a digitalis effect). All 12 arrhythmia types of the cardiopulmonary bypass group, as well as the separately considered ventricular arrhythmias of the first "arrhythmia peak", did not reveal any significant relation to: patients' age, total anaesthesia time, total surgery time and total bypass time. It is recognized that any comparative evaluation of operative arrhythmias, and especially a study of the causes and development of "surgically induced" A-V block, is problematic.
在一组随机选取的38例患者中,研究了12种与先天性心脏病手术相关的心律失常。采用氟烷进行麻醉,并用普鲁卡因-镁-天冬氨酸溶液诱导心脏停搏。在术中和术后早期的10个不同时间点进行心律失常的记录和分析,这些时间点间隔较近,之后直到观察的第96小时间隔逐渐增大。给出了每例患者的心律失常发生率、每例患者及各阶段的心律失常发生情况,从而也能对短暂性心律失常进行统计。术中心律失常的发生高峰出现在主动脉阻断和开放时(缺血和氟烷作用)。体外循环后第1至6小时心律失常发生率下降,随后在术后第6至23小时出现第二个高峰(电解质和酸碱紊乱和/或洋地黄效应)。体外循环组的所有12种心律失常类型,以及首次“心律失常高峰”中单独考虑的室性心律失常,均与患者年龄、总麻醉时间、总手术时间和总体外循环时间无显著关系。人们认识到,对手术心律失常进行任何比较性评估,尤其是对“手术诱发”房室传导阻滞的原因和发展进行研究,都存在问题。