新型隐球菌中的黑色素生物合成。
Melanin biosynthesis in Cryptococcus neoformans.
作者信息
Williamson P R, Wakamatsu K, Ito S
机构信息
Division of Infectious Diseases, University of Illinois at Chicago College of Medicine, 60612, USA.
出版信息
J Bacteriol. 1998 Mar;180(6):1570-2. doi: 10.1128/JB.180.6.1570-1572.1998.
Abstract
Pigment production by Cryptococcus neoformans is virulence associated. Dopamine- and 3,4-dihydroxyphenylalanine-melanin products were identified after acidic permanganate oxidation, alkaline hydrogen peroxide oxidation, or hydrolysis with hydriodic acid. These data provide direct chemical evidence for the formation of eumelanin polymers by catecholamine oxidation by laccase alone followed by oxidative coupling of dihydroxyindole.
摘要
新型隐球菌产生色素与毒力相关。在酸性高锰酸钾氧化、碱性过氧化氢氧化或氢碘酸水解后，鉴定出多巴胺和3,4-二羟基苯丙氨酸-黑色素产物。这些数据为仅由漆酶通过儿茶酚胺氧化形成真黑素聚合物，随后二羟基吲哚进行氧化偶联提供了直接的化学证据。
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