健康志愿者进食半固体食物后对乙酰氨基酚吸收动力学的个体内变异性。
Intraindividual variability of paracetamol absorption kinetics after a semi-solid meal in healthy volunteers.
作者信息
Paintaud G, Thibault P, Queneau P E, Magnette J, Bérard M, Rumbach L, Bechtel P R, Carayon P
机构信息
Department of Clinical Pharmacology, Jean-Minjoz University Hospital, Besançon, France.
出版信息
Eur J Clin Pharmacol. 1998 Jan;53(5):355-9. doi: 10.1007/s002280050393.
OBJECTIVE
The absorption kinetics of paracetamol is dependent on gastric emptying and its measurement was proposed as a non-invasive method to estimate gastric emptying rate. The objective of this study was to evaluate the intraindividual variability of paracetamol absorption kinetics after a semi-solid meal.
METHODS
The pharmacokinetics of paracetamol was studied on two occasions in 15 healthy volunteers without Helicobacter pylori antibodies. A 1-g dose of paracetamol was given as a solution together with a standardised semi-solid meal and the subjects stayed in the supine position.
RESULTS
For most of the subjects, the time course of paracetamol concentrations was similar on the two occasions. The intraindividual variability was low, with coefficients of variation of 38.3%, 8.0% and 3.8% for time to maximum plasma concentration, maximum concentration and area under the plasma concentration - time curve until 6 h, respectively.
CONCLUSION
The assessment of paracetamol absorption kinetics is reproducible when the drug is given together with a semi-solid meal in Helicobacter pylori-negative healthy subjects.
目的
对乙酰氨基酚的吸收动力学取决于胃排空，其测量被提议作为一种估计胃排空率的非侵入性方法。本研究的目的是评估半固体餐后对乙酰氨基酚吸收动力学的个体内变异性。
方法
在15名无幽门螺杆菌抗体的健康志愿者中，分两次研究了对乙酰氨基酚的药代动力学。给予1克对乙酰氨基酚溶液并搭配标准化半固体餐，受试者保持仰卧位。
结果
对于大多数受试者，两次测量时对乙酰氨基酚浓度的时间进程相似。个体内变异性较低，血浆浓度达峰时间、最大浓度以及血浆浓度-时间曲线下6小时面积的变异系数分别为38.3%、8.0%和3.8%。
结论
在幽门螺杆菌阴性的健康受试者中，当药物与半固体餐一起给予时，对乙酰氨基酚吸收动力学的评估具有可重复性。
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