Penn A A, Riquelme P A, Feller M B, Shatz C J
Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Science. 1998 Mar 27;279(5359):2108-12. doi: 10.1126/science.279.5359.2108.
When contacts are first forming in the developing nervous system, many neurons generate spontaneous activity that has been hypothesized to shape appropriately patterned connections. In Mustela putorius furo, monocular intraocular blockade of spontaneous retinal waves of action potentials by cholinergic agents altered the subsequent eye-specific lamination pattern of the lateral geniculate nucleus (LGN). The projection from the active retina was greatly expanded into territory normally belonging to the other eye, and the projection from the inactive retina was substantially reduced. Thus, interocular competition driven by endogenous retinal activity determines the pattern of eye-specific connections from retina to LGN, demonstrating that spontaneous activity can produce highly stereotyped patterns of connections before the onset of visual experience.
在发育中的神经系统中，当突触最初形成时，许多神经元会产生自发活动，据推测这种活动会塑造出模式适当的连接。在雪貂中，胆碱能药物对视网膜动作电位的自发视网膜波进行单眼眼内阻断，改变了外侧膝状体（LGN）随后的眼特异性分层模式。来自活跃视网膜的投射大幅扩展到通常属于另一只眼睛的区域，而来自不活跃视网膜的投射则大幅减少。因此，由内源性视网膜活动驱动的眼间竞争决定了从视网膜到LGN的眼特异性连接模式，这表明自发活动可以在视觉经验开始之前产生高度刻板的连接模式。
