Batts K F, Munter D W
Emergency Medicine Department, Naval Medical Center, Portsmouth, Virginia 23708, USA.
Pediatr Emerg Care. 1998 Feb;14(1):39-41. doi: 10.1097/00006565-199802000-00011.
Metoclopramide (4-amino-5-chloro-N-2-methoxybenzamide) is a central and peripheral acting dopamine antagonist. It also stimulates motility in the upper gastrointestinal tract and increases lower esophageal sphincter pressure. In the pediatric population, it is used extensively as an antiemetic and in the treatment of gastroesophageal reflux disease. The case of a six-month-old infant who was accidentally overdosed with 24 mg (3 mg/kg) of metoclopramide within a nine-hour period is presented. The patient demonstrated toxic extrapyramidal effects. There have been multiple early reports in the European literature of acute extrapyramidal reactions in the pediatric population, but no reports of toxicity exist in the current emergency medicine literature.
甲氧氯普胺（4-氨基-5-氯-N-2-甲氧基苯甲酰胺）是一种中枢和外周作用的多巴胺拮抗剂。它还能刺激上消化道的蠕动并增加食管下括约肌压力。在儿科人群中，它被广泛用作止吐药和治疗胃食管反流病。本文介绍了一名6个月大的婴儿在9小时内意外过量服用24毫克（3毫克/千克）甲氧氯普胺的病例。该患者出现了中毒性锥体外系反应。欧洲文献中有多篇关于儿科人群急性锥体外系反应的早期报道，但当前急诊医学文献中尚无毒性报告。
