Tagliabue E, Ghirelli C, Squicciarini P, Aiello P, Colnaghi M I, Ménard S
Division of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy.
Clin Cancer Res. 1998 Feb;4(2):407-10.
Immunocytochemical analysis of breast carcinoma specimens for alpha 6 beta 4 integrin expression and other different pathobiological markers revealed beta 4 integrin subunit expression in 36 of 80 cases analyzed and a significant association only with alpha 6 integrin subunit expression (P < 0.01) and laminin production (P = 0.01) by tumor cells. Survival analysis indicated that beta 4 and alpha 6 expression are associated with poor prognosis (P = 0.02), whereas laminin production showed only borderline association (P = 0.06). However, analysis of disease outcome in relation to expression of both alpha 6 beta 4 and laminin indicated best outcomes for patients with tumors producing laminin but not expressing alpha 6 beta 4 integrin, whereas worst outcomes were observed for alpha 6 beta 4- and laminin-positive tumors, indicating that alpha 6 beta 4 expression was associated with prognosis, mainly in the laminin-producing tumor subset. These data indicate that the prognostic value of alpha 6 beta 4 integrin expression is affected by laminin production from tumor cells and suggest that interaction between these two molecules mediates distinct signals that are important for tumor progression.
对乳腺癌标本进行免疫细胞化学分析，检测α6β4整合素表达及其他不同的病理生物学标志物，结果显示，在分析的80例病例中，有36例出现β4整合素亚基表达，且仅与肿瘤细胞的α6整合素亚基表达（P < 0.01）和层粘连蛋白产生（P = 0.01）存在显著关联。生存分析表明，β4和α6表达与预后不良相关（P = 0.02），而层粘连蛋白产生仅显示临界关联（P = 0.06）。然而，对疾病转归与α6β4和层粘连蛋白表达关系的分析表明，对于产生层粘连蛋白但不表达α6β4整合素的肿瘤患者，预后最佳；而对于α6β4和层粘连蛋白均阳性的肿瘤患者，预后最差，这表明α6β4表达与预后相关，主要体现在产生层粘连蛋白的肿瘤亚组中。这些数据表明，α6β4整合素表达的预后价值受肿瘤细胞层粘连蛋白产生的影响，并提示这两种分子之间的相互作用介导了对肿瘤进展至关重要的不同信号。
