全州范围内对ABO血型匹配的单供体血小板的血小板减少症患者的支持。

Statewide support of thrombocytopenic patients with ABO matched single donor platelets.

作者信息

Reiss R F, Katz A J

出版信息

Transfusion. 1976 Jul-Aug;16(4):312-20. doi: 10.1046/j.1537-2995.1976.16476247051.x.

DOI:10.1046/j.1537-2995.1976.16476247051.x

Abstract

Use of ABO matched, HLA nonmatched platelet units obtained from single donors by pheresis, using the Haemonetics 30 Cell Separator, has a lowered hepatitis risk, and possibly delays the onset of the refractory state. Pheresis also offers a method of obtaining HLA matched platelets for the already refractory patient. A mean of 4.2 X 10(11) platelets are collected in about 1 1/2 hours. ABO matched, HLA nonmatched platelets produced corrected increments of more than 2500/mm3 per 7 X 10(10) platelets infused in 67 per cent of transfusions to nonselected recipients. The procedure is simple, safe, and requires little time. It is a worthwhile large-scale program for a regional blood center to undertake in order to provide optimal therapy for thrombocytopenic patients.

摘要

使用通过血细胞分离术从单采供血者获得的 ABO 血型匹配、HLA 不匹配的血小板单位，使用 Haemonetics 30 细胞分离器，可降低肝炎风险，并可能延迟难治状态的出现。血细胞分离术还为已经难治的患者提供了一种获得 HLA 匹配血小板的方法。在约 1.5 小时内平均采集 4.2×10¹¹ 个血小板。在向未选择的受血者进行的 67% 的输血中，ABO 血型匹配、HLA 不匹配的血小板每输注 7×10¹⁰ 个血小板产生的校正增加值超过 2500/mm³。该程序简单、安全，所需时间少。对于地区血液中心来说，这是一个值得开展的大规模项目，以便为血小板减少症患者提供最佳治疗。