Jartti T T, Kuusela T A, Kaila T J, Tahvanainen K U, Välimäki I A
Department of Paediatrics, Turku University Hospital, Finland.
Br J Clin Pharmacol. 1998 Mar;45(3):277-85. doi: 10.1046/j.1365-2125.1998.00674.x.
To study the dose-response effects of intravenous terbutaline on the cardiovascular and respiratory autonomic nervous regulation.
The study followed a randomized, placebo-controlled crossover design in six healthy adult volunteers. The terbutaline dose ranged from 10 to 30 microg min(-1) We continuously measured electrocardiogram, finger systolic arterial pressure (SAP) and flow-volume spirometry in supine and upright positions at baseline and during 3 h drug infusion. The periodic variability components of R-R intervals (time between successive heart beats) and SAP in relation to respiration were assessed using spectral analysis techniques. The regularity of the time series was assessed by approximate entropy (ApEn) and the convolutedness by fractal dimension (FD).
Terbutaline dose-dependently decreased total variability of R-R intervals, low frequency (LF) variability of R-R intervals (10 s waves), high frequency (HF) variability of R-R intervals (respiratory variability), total variability of SAP, HF variability of SAP, baroreflex sensitivity, plasma potassium concentration, approximate entropy of R-R interval and of SAP as well as fractal dimension of R-R interval. Terbutaline dose-dependently increased heart rate, LF/HF ratios of R-R intervals and of SAP, LF variability of SAP, minute ventilation and plasma terbutaline concentration.
Terbutaline infusion decreases parasympathetic cardiovascular reactivity, baroreflex sensitivity, dimensionality of heart rate and plasma potassium concentration; it increases sympathetic dominance in cardiovascular autonomic balance, minute ventilation, and the regularity of heart rate and blood pressure time series.
研究静脉注射特布他林对心血管和呼吸自主神经调节的剂量反应效应。
本研究采用随机、安慰剂对照交叉设计，纳入6名健康成年志愿者。特布他林剂量范围为10至30微克/分钟（-1）。我们在基线及药物输注3小时期间，持续测量仰卧位和直立位的心电图、手指收缩期动脉压（SAP）和流速容量肺活量。使用频谱分析技术评估与呼吸相关的R-R间期（连续心跳之间的时间）和SAP的周期性变异性成分。通过近似熵（ApEn）评估时间序列的规律性，通过分形维数（FD）评估其复杂性。
特布他林剂量依赖性地降低R-R间期的总变异性、R-R间期的低频（LF）变异性（10秒波）、R-R间期的高频（HF）变异性（呼吸变异性）、SAP的总变异性、SAP的HF变异性、压力反射敏感性、血浆钾浓度、R-R间期和SAP的近似熵以及R-R间期的分形维数。特布他林剂量依赖性地增加心率、R-R间期和SAP的LF/HF比值、SAP的LF变异性、分钟通气量和血浆特布他林浓度。
输注特布他林可降低副交感神经心血管反应性、压力反射敏感性、心率维度和血浆钾浓度；增加心血管自主平衡中交感神经的优势、分钟通气量以及心率和血压时间序列的规律性。
