Zakrgynska-Fontaine V, Doré J C, Ojasoo T, Poirier-Duchêne F, Viel C
Faculty of Pharmacy, Tours University, France.
Biol Trace Elem Res. 1998 Feb;61(2):151-68. doi: 10.1007/BF02784027.
The aim of the study was to examine the potential of multidimensional analysis, and in particular of correspondence analysis (CA), in bringing to light the influence of sex and age on trace element (TE) concentrations in hair from an unselected French population. Sixteen elements (S, Hg, Se, Zn, Pb, Cd, Ni, Co, Mn, Fe, Cr, Mg, Al, Ca, Cu, Ag) were assayed by inductively coupled argon plasma (ICAP) emission spectroscopy in the scalp hair of 135 men and 346 women. In spite of the high background noise, CA was able to reveal the differing patterns in males and females. For instance, in this population, higher relative levels of the essential elements, Ca, Mg, Zn, and Cu, but also of Ag, characterized women's hair, whereas higher relative levels of the heavy metals, Fe and Pb, were associated with men's hair. Al and Ag were unexplainedly high in the hair of the youngest members of the population. The Cu and Co of youth seemed to give way to a predominance of Zn in maturity. The hair of individuals in their forties tended to be richest in Ca and Mg, but these elements decreased with advancing age. Heavy metals (Hg, Pb, Fe) accumulated with age, whereas Se, Mn, and Cr seemed independent of age. CA is manifestly a very useful tool for revealing underlying dimensions in complex dynamic systems and unsuspected relationships among variables. Clearly, the significance of the high Al and Ag contents in the hair of certain members of the population, especially of the very young, needs to be investigated from both physiological and toxicological aspects.
该研究的目的是检验多维分析，特别是对应分析（CA），揭示性别和年龄对来自未经过筛选的法国人群头发中微量元素（TE）浓度影响的潜力。通过电感耦合氩等离子体（ICAP）发射光谱法对135名男性和346名女性的头皮头发中的16种元素（硫、汞、硒、锌、铅、镉、镍、钴、锰、铁、铬、镁、铝、钙、铜、银）进行了测定。尽管背景噪声很高，但对应分析仍能够揭示男性和女性之间不同的模式。例如，在这个人群中，女性头发的特征是必需元素钙、镁、锌、铜以及银的相对含量较高，而男性头发则与重金属铁和铅的相对含量较高有关。在该人群最年轻成员的头发中，铝和银的含量莫名偏高。年轻人头发中的铜和钴在成年后似乎被锌的优势所取代。四十多岁人群的头发往往钙和镁含量最丰富，但随着年龄增长这些元素含量会下降。重金属（汞、铅、铁）随年龄积累，而硒、锰和铬似乎与年龄无关。对应分析显然是揭示复杂动态系统中潜在维度以及变量间意外关系的非常有用的工具。显然，需要从生理和毒理学两方面对人群中某些成员，尤其是非常年轻成员头发中高铝和高银含量的意义进行研究。
