Department of Family Medicine, Kyungpook National University Hospital, Daegu 41944, Korea.
Department of Family Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Nutrients. 2019 Mar 15;11(3):637. doi: 10.3390/nu11030637.
This cross-sectional analysis included 137 Korean subjects aged 60⁻79 years. All subjects underwent anthropometric measurements and laboratory tests. Scalp hair samples were obtained from each individual, the concentrations of 36 minerals and trace elements were analyzed, and 16 ratios of elements were calculated. ASCVD risk was estimated using pooled cohort ASCVD risk assessment equations for 10-year risk profiles. The 137 subjects were divided into three risk groups: low (<5%, = 28), intermediate (5% to <7.5%, = 21), and high (≥7.5%, = 88) risk groups. After adjusting for obesity (BMI ≥ 25 kg/m²) and sex, Na concentration (mg%) in hair was significantly lower in the low-risk (13.91 ± 7.02) than in the intermediate-risk (47.18 ± 8.08) and high-risk (36.76 ± 3.95) groups ( for trend = 0.024). The concentration of K (mg%) in hair was also positively associated with the severity of ASCVD risk (10.50 ± 8.37, 23.62 ± 9.63, 33.31 ± 4.71, respectively; for trend = 0.017), but their differences were not statistically significant ( = 0.059). By contrast, the levels of Co, U, and Hg, and the Ca/P and Ca/Mg ratios, were negatively correlated with the severity of ASCVD risk ( for trend < 0.05). Mean Na concentration in hair was significantly lower in the low-risk than in the other risk groups. By contrast, Co, U, and Hg concentrations showed significant negative associations with risk severity. Further studies are needed to assess whether dietary modification for trace elements could lower the risk of ASCVD.
本横断面分析纳入了 137 名年龄在 60-79 岁的韩国受试者。所有受试者均接受了人体测量学和实验室检查。从每个个体中获取头皮头发样本,分析 36 种矿物质和微量元素的浓度,并计算 16 种元素的比值。使用 pooled cohort ASCVD risk assessment equations 计算 10 年风险曲线来评估 ASCVD 风险。137 名受试者分为三组:低危组(<5%, = 28)、中危组(5%至<7.5%, = 21)和高危组(≥7.5%, = 88)。在校正肥胖(BMI≥25 kg/m²)和性别后,低危组(13.91 ± 7.02)的头发中 Na 浓度(mg%)明显低于中危组(47.18 ± 8.08)和高危组(36.76 ± 3.95)(趋势检验= 0.024)。头发中 K(mg%)的浓度也与 ASCVD 风险的严重程度呈正相关(分别为 10.50 ± 8.37、23.62 ± 9.63、33.31 ± 4.71;趋势检验= 0.017),但差异无统计学意义(= 0.059)。相比之下,Co、U 和 Hg 的水平以及 Ca/P 和 Ca/Mg 比值与 ASCVD 风险的严重程度呈负相关(趋势检验<0.05)。低危组头发中 Na 浓度明显低于其他风险组。相比之下,Co、U 和 Hg 浓度与风险严重程度呈显著负相关。需要进一步研究来评估微量元素的饮食调整是否可以降低 ASCVD 的风险。