Toda S, Yase Y
Department of Biochemistry, Kansai College of Oriental Medicine, Sennan, Osaka, Japan.
Biol Trace Elem Res. 1998 Feb;61(2):207-17. doi: 10.1007/BF02784031.
In the present study the authors report on the enhancing effect of aluminum(III) (Al[III]) on iron(II)(Fe[II])-induced lipid peroxidation (LPO) of mice brain homogenate, which occurs in a concentration- and time-dependent manner. No evidence of LPO caused by Al alone was found. Both Al(III) and Fe(II) ions induced protein oxidative modifications in mice brain homogenate, in a time- and concentration-dependent manner. Aluminum enhances Fe(II)-induced protein oxidative modification at a concentration of 2:1 and 1:1 Al:Fe molar ratios. However, Al suppress Fe(II)-induced protein oxidative modification at a concentration of 0.5:1 Al:Fe molar ratio. Addition of ethylenediaminetetraacetic acid (EDTA) inhibits both LPO and protein oxidative modifications induced by Al(III) and Fe(II) ions. Addition of mannitol and of superoxide dismutase (SOD) did not show such effects. It is concluded that in mice brain homogenate, Al accelerates Fe(II)-induced LPO. Protein oxidative modifications caused by Fe(II) and/or Al ions are enhanced at high, but suppressed at low concentrations of Al ions. The latter observation suggests a possible biological role of Al as an antioxidant.
在本研究中，作者报告了铝（III）（Al[III]）对铁（II）（Fe[II]）诱导的小鼠脑匀浆脂质过氧化（LPO）的增强作用，这种作用呈浓度和时间依赖性。未发现单独由铝引起的LPO证据。Al（III）和Fe（II）离子均以时间和浓度依赖性方式诱导小鼠脑匀浆中的蛋白质氧化修饰。铝在Al:Fe摩尔比为2:1和1:1时增强Fe（II）诱导的蛋白质氧化修饰。然而，铝在Al:Fe摩尔比为0.5:1时抑制Fe（II）诱导的蛋白质氧化修饰。添加乙二胺四乙酸（EDTA）可抑制Al（III）和Fe（II）离子诱导的LPO和蛋白质氧化修饰。添加甘露醇和超氧化物歧化酶（SOD）未显示出此类作用。得出的结论是，在小鼠脑匀浆中，铝加速Fe（II）诱导的LPO。由Fe（II）和/或铝离子引起的蛋白质氧化修饰在高浓度铝离子时增强，但在低浓度铝离子时受到抑制。后一观察结果表明铝作为抗氧化剂可能具有生物学作用。
