Zhang Y, Burk J A, Glode B M, Mair R G
Department of Psychology, University of New Hampshire, Durham 03824, USA.
Behav Neurosci. 1998 Feb;112(1):39-53. doi: 10.1037//0735-7044.112.1.39.
We conducted 2 studies to determine the importance of several brain systems for remembering odorants in a go/no-go delayed nonmatching-to-sample (DNMTS) task. In Experiment 1, impairments were observed for lesions of pyriform cortex or (to a lesser extent) the lateral internal medullary lamina of thalamus. Lesions of the entorhinal cortex or the mediodorsal (MDn) or the paracentral and centrolateral (PC-CL) thalamic nuclei did not affect DNMTS. In Experiment 2, an impairment comparable to the pyriform lesion was observed for a lesion of the intralaminar nuclei (PC-CL plus the central medial nucleus) but not for a larger lesion of MDn. None of the lesions in either study affected the ability to learn a 2-choice odor discrimination using go/no-go procedures comparable with the DNMTS task.
我们进行了两项研究，以确定在“是/否”延迟非匹配样本（DNMTS）任务中，几个脑系统对记忆气味剂的重要性。在实验1中，观察到梨状皮层或（程度较轻的）丘脑外侧髓板损伤会导致功能受损。内嗅皮层、丘脑背内侧核（MDn）或丘脑中央旁核和中央外侧核（PC-CL）损伤并不影响DNMTS。在实验2中，观察到板内核（PC-CL加上中央内侧核）损伤导致的功能受损程度与梨状皮层损伤相当，但MDn较大损伤则不然。两项研究中的任何损伤均未影响使用与DNMTS任务类似的“是/否”程序学习二选一气味辨别的能力。
