Cover Kara K, Mathur Brian N
Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, United States.
Front Behav Neurosci. 2021 Apr 15;15:652764. doi: 10.3389/fnbeh.2021.652764. eCollection 2021.
The thalamic rostral intralaminar nuclei (rILN) are a contiguous band of neurons that include the central medial, paracentral, and central lateral nuclei. The rILN differ from both thalamic relay nuclei, such as the lateral geniculate nucleus, and caudal intralaminar nuclei, such as the parafascicular nucleus, in afferent and efferent connectivity as well as physiological and synaptic properties. rILN activity is associated with a range of neural functions and behaviors, including arousal, pain, executive function, and action control. Here, we review this evidence supporting a role for the rILN in integrating arousal, executive and motor feedback information. In light of rILN projections out to the striatum, amygdala, and sensory as well as executive cortices, we propose that such a function enables the rILN to modulate cognitive and motor resources to meet task-dependent behavioral engagement demands.
丘脑嘴侧层内核（rILN）是由中央内侧核、中央旁核和中央外侧核组成的连续神经元带。rILN在传入和传出连接以及生理和突触特性方面，与丘脑中继核（如外侧膝状体核）和尾侧层内核（如束旁核）均有所不同。rILN的活动与一系列神经功能和行为相关，包括觉醒、疼痛、执行功能和动作控制。在此，我们综述支持rILN在整合觉醒、执行和运动反馈信息中发挥作用的证据。鉴于rILN投射至纹状体、杏仁核、感觉皮层以及执行皮层，我们提出这种功能使rILN能够调节认知和运动资源，以满足任务相关的行为参与需求。
