耐甲氧西林金黄色葡萄球菌和表皮葡萄球菌mecI基因及mecA启动子/操纵子区域突变多样性分析
Analysis of diversity of mutations in the mecI gene and mecA promoter/operator region of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.
作者信息
Kobayashi N, Taniguchi K, Urasawa S
机构信息
Department of Hygiene, Sapporo Medical University School of Medicine, Japan.
出版信息
Antimicrob Agents Chemother. 1998 Mar;42(3):717-20. doi: 10.1128/AAC.42.3.717.
Abstract
Genomic diversity of mutation in the mecI gene or mecA promoter/operator region was analyzed for clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE). In most MRSA strains, a single base substitution was detected in either the mecI (three different positions) or the mecA promoter (two different positions), while a 28-base deletion in mecI was found in one strain. In contrast, no mutation was detected in these gene sequences of MRSE strains.
摘要
对耐甲氧西林金黄色葡萄球菌（MRSA）和表皮葡萄球菌（MRSE）的临床分离株，分析了mecI基因或mecA启动子/操纵子区域的突变基因组多样性。在大多数MRSA菌株中，在mecI（三个不同位置）或mecA启动子（两个不同位置）中检测到单个碱基替换，而在一个菌株中发现mecI有28个碱基的缺失。相比之下，在MRSE菌株的这些基因序列中未检测到突变。
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