Konarska A
Klinika Otolaryngologii Pomorskiej Akademii Medycznej w Szczecinie.
Otolaryngol Pol. 1997;51(2):183-90.
The study dealing with the content of fluoride and calcium in stapedial bone and canal wall bone in otosclerosis was performed in 69 subjects (48 females and 21 males) out of the patients, in whom bone rebuilding activity had earlier been studied isotopically. The control group comprised 20 normal stapedies taken during autopsies. Fluoride content was determined by means of fluoride ions meter, the content of calcium was assessed by resorting to atomic absorptiometer. The content of studied elements was compared with the bone rebuilding activity and some clinical features such as the patient's age and duration of the disease. High fluoride content in otosclerotic stapes was revealed, being several times greater than in the bone of normal stapes. Concurrently the stapedial bone in otosclerosis contained less calcium as compared with the bone of normal stapes. In principle, that referred to otosclerotic focus and next to stapedial crura. The bones of stapedial footplates and otosclerotic foci with rebuilding activity lover han the means value had statistically significant, higher content of fluoride and calcium than the bones with greater rebuilding activity. Fluoride content in stapedial bone during otosclerosis dramatically increased with the patient's age and the length of the disease duration period, however, the calcium content had the tendency to decrease.
对耳硬化症患者镫骨和耳道壁骨中的氟和钙含量进行的研究共纳入了69名受试者（48名女性和21名男性），这些患者此前已通过同位素方法研究过骨重建活动。对照组由尸检时获取的20个正常镫骨组成。氟含量通过氟离子计测定，钙含量通过原子吸收仪评估。将所研究元素的含量与骨重建活动以及一些临床特征（如患者年龄和病程）进行比较。结果显示，耳硬化症镫骨中的氟含量较高，比正常镫骨中的骨氟含量高出数倍。同时，与正常镫骨相比，耳硬化症中的镫骨含钙量较少。原则上，这适用于耳硬化病灶及镫骨脚。重建活动低于平均值的镫骨底板和耳硬化病灶的骨，其氟和钙含量在统计学上显著高于重建活动较强的骨。耳硬化症患者镫骨中的氟含量随患者年龄和病程的延长而急剧增加，然而，钙含量则有下降趋势。
