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早期糖酵解中间产物可调节脂肪酸与大鼠肝脏脂肪酸结合蛋白的结合。

Fatty acid binding to rat liver fatty acid-binding protein is modulated by early glycolytic intermediates.

作者信息

Stewart J M, Dewling V F, Wright T G

机构信息

Department of Biology and Biochemistry, Mount Allison University, Sackville, New Brunswick, Canada.

出版信息

Biochim Biophys Acta. 1998 Mar 6;1391(1):1-6. doi: 10.1016/s0005-2760(97)00202-6.

DOI:10.1016/s0005-2760(97)00202-6
PMID:9518529
Abstract

Fatty acid binding to rat liver fatty acid binding protein in the presence of glycolytic metabolites and at different pH (optimal 7.2) and ionic strength was studied. Binding decreased logarithmically with ionic strength. Glucose and glucose-6-phosphate increased fatty acid binding significantly with K0.5 within physiological ranges while glucose-1-phosphate and phosphate ion caused no effect.

摘要

研究了在糖酵解代谢产物存在下，以及在不同pH（最适pH为7.2）和离子强度条件下，脂肪酸与大鼠肝脏脂肪酸结合蛋白的结合情况。结合量随离子强度呈对数下降。葡萄糖和6-磷酸葡萄糖在生理范围内显著增加脂肪酸结合，其半数效应浓度（K0.5）在生理范围内，而1-磷酸葡萄糖和磷酸离子则无影响。

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Biochim Biophys Acta. 1998 Mar 6;1391(1):1-6. doi: 10.1016/s0005-2760(97)00202-6.
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Biochem J. 1996 Mar 15;314 ( Pt 3)(Pt 3):943-9. doi: 10.1042/bj3140943.

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