Torigoe K, Awaya A
Department of Anatomy, Fukui Medical School, Matsuoka, Fukui 910-1193, Japan.
Brain Res. 1998 Mar 23;787(2):337-40. doi: 10.1016/s0006-8993(97)01491-1.
Following transection of a peripheral nerve in mice, a newly synthesized neurotropic pyrimidine compound, MS-818 was administered intraperitoneally at a dose of 1 mg kg-1 b.wt. day-1. The film model experiments for analyzing the early growth of axonal regeneration suggested that MS-818 activated Schwann cells which migrate from the proximal stump, inducing axonal elongation in vivo.
在小鼠外周神经横断后，以1毫克/千克体重/天的剂量腹腔注射新合成的嗜神经嘧啶化合物MS - 818。用于分析轴突再生早期生长的薄膜模型实验表明，MS - 818激活了从近端残端迁移过来的雪旺细胞，在体内诱导轴突伸长。
