电压门控钠通道的结构与功能。
Structure and function of voltage-gated sodium channels.
作者信息
Marban E, Yamagishi T, Tomaselli G F
机构信息
Section of Molecular and Cellular Cardiology, The Johns Hopkins University, Baltimore, MD 21205, USA.
出版信息
J Physiol. 1998 May 1;508 ( Pt 3)(Pt 3):647-57. doi: 10.1111/j.1469-7793.1998.647bp.x.
Abstract
- Sodium channels mediate fast depolarization and conduct electrical impulses throughout nerve, muscle and heart. This paper reviews the links between sodium channel structure and function. 2. Sodium channels have a modular architecture, with distinct regions for the pore and the gates. The separation is far from absolute, however, with extensive interaction among the various parts of the channel. 3. At a molecular level, sodium channels are not static: they move extensively in the course of gating and ion translocation. 4. Sodium channels bind local anaesthetics and various toxins. In some cases, the relevant sites have been partially identified. 5. Sodium channels are subject to regulation at the levels of transcription, subunit interaction and post-translational modification (notably glycosylation and phosphorylation).
摘要
- 钠通道介导快速去极化，并在神经、肌肉和心脏中传导电冲动。本文综述了钠通道结构与功能之间的联系。2. 钠通道具有模块化结构，有用于孔道和门控的不同区域。然而，这种分隔并非绝对，通道各部分之间存在广泛相互作用。3. 在分子水平上，钠通道并非静止不变：它们在门控和离子转运过程中会发生广泛移动。4. 钠通道可结合局部麻醉药和各种毒素。在某些情况下，相关位点已被部分确定。5. 钠通道在转录、亚基相互作用和翻译后修饰（尤其是糖基化和磷酸化）水平上受到调控。
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