在抑肽酶治疗的小鼠中，角叉菜胶诱导的免疫抑制得以保留，同时毒性减轻。
Preservation of carrageenan-induced immune suppression with alleviation of toxicity in aprotinin-treated mice.
作者信息
Fowler E F, Thomson A W
出版信息
Int J Immunopharmacol. 1979;1(1):69-72. doi: 10.1016/0192-0561(79)90033-x.
PMID:95188
Abstract
Although the immunosuppressive effect of carrageenan was unimpaired in aprotinin-treated mice, the extent of intravascular coagulation induced by this macrophage toxic agent was substantially reduced. Use of antiproteases such as aprotinin may prove beneficial in management of this adverse side effect of certain immunotherapeutic agents.
摘要
尽管在抑肽酶处理的小鼠中角叉菜胶的免疫抑制作用未受损害，但这种巨噬细胞毒性剂诱导的血管内凝血程度大幅降低。使用抗蛋白酶如抑肽酶可能被证明对管理某些免疫治疗剂的这种不良副作用有益。
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