Hähnel S, Heiland S, Jansen O, Freund M, Sartor K
Abt. Neuroradiologie, Universität Heidelberg.
Rofo. 1998 Feb;168(2):185-90. doi: 10.1055/s-2007-1015206.
A new application for magnetization transfer (MT) MR imaging is the investigation of cerebral white matter. For that a pure MT effect is desirable. Our purpose was the optimization and testing of an MT sequence for investigations of cerebral white matter.
Experimental investigations were performed in phantom material and in 5 wistar rats using various frequency offsets (FO) (200 Hz-30,000 Hz). Relative signal suppression (rSS) for the phantom material and for callosal white matter of the rat was calculated. The optimized sequence was tested in 25 healthy volunteers.
A relatively pure MT effect was achieved with FO > 4000 Hz. rSS for cerebral white matter structures was generally higher than rSS für cerebral gray matter structures. rSS for cerebral white matter structures ranged from 45-50%.
We present a fast MT sequence with high rSS for cerebral white matter and a relatively pure MT effect. Owing to the high rSS-values we expect that this sequence improves differentiation of cerebral white matter lesions. Because of the confusing variety of MT sequence currently described in the literature we believe that standard parameters should be defined to make published results comparable.
磁化传递（MT）磁共振成像的一项新应用是对脑白质进行研究。为此，需要一个纯粹的MT效应。我们的目的是优化和测试一种用于脑白质研究的MT序列。
使用各种频率偏移（FO）（200Hz - 30000Hz），在模型材料和5只Wistar大鼠上进行了实验研究。计算了模型材料和大鼠胼胝体白质的相对信号抑制（rSS）。在25名健康志愿者身上测试了优化后的序列。
当FO > 4000Hz时，可实现相对纯粹的MT效应。脑白质结构的rSS通常高于脑灰质结构的rSS。脑白质结构的rSS范围为45% - 50%。
我们提出了一种用于脑白质的具有高rSS和相对纯粹MT效应的快速MT序列。由于rSS值较高，我们预计该序列可改善脑白质病变的鉴别。鉴于目前文献中描述的MT序列种类繁多令人困惑，我们认为应定义标准参数以使发表的结果具有可比性。
