Fiz J A, Abad J, Ruiz J, Riera M, Izquierdo J, Morera J
Pneumology Department, Germans Trias i Pujol Hospital, Badalona, Spain.
Respir Med. 1998 Jan;92(1):28-31. doi: 10.1016/s0954-6111(98)90028-2.
This study has investigated the effect of interrupting nasal continuous positive airway pressure (nCPAP) therapy on 10 obstructive sleep apnoea (OSA) patients (nine male, one female) (53.6 +/- 7.3 years) treated over 2 years. The effect of nCPAP interruption was determined by variations in sleep counts and gasometric values during five consecutive nights. On the first night, the patient used his habitual nCPAP. On the remaining nights, nasal nCPAP was not applied. The apnoea-hypopnoea index (AHI) was found to increase significantly in the second night, attaining a similar level to that of the basal study (2 years ago). SaO2 minimum decreased and PaCO2 increased in the second night with respect to the first night. The interruption of nCPAP therapy in OSA patients treated over a long period of time increases the sleep counts and impairs the gasometric parameters. Consequently, any change in nCPAP time therapy must be checked to avoid negative effects.
本研究调查了中断鼻持续气道正压通气（nCPAP）治疗对10例阻塞性睡眠呼吸暂停（OSA）患者（9例男性，1例女性）（53.6±7.3岁）的影响，这些患者接受了超过2年的治疗。通过连续五个晚上的睡眠计数和气体测量值变化来确定nCPAP中断的影响。在第一个晚上，患者使用其习惯的nCPAP。在其余晚上，不应用鼻nCPAP。发现呼吸暂停低通气指数（AHI）在第二个晚上显著增加，达到与基础研究（2年前）相似的水平。与第一个晚上相比，第二个晚上的最低血氧饱和度（SaO2）下降，二氧化碳分压（PaCO2）升高。长期接受治疗的OSA患者中断nCPAP治疗会增加睡眠计数并损害气体测量参数。因此，必须检查nCPAP治疗时间的任何变化，以避免产生负面影响。
