Marín Bivens C L, Thomas W J, Stanley B G
Department of Psychology, University of California, Santa Barbara 93106, USA.
Brain Res. 1998 Jan 26;782(1-2):271-80. doi: 10.1016/s0006-8993(97)01289-4.
Although hypothalamic injections of neuropeptide Y (NPY) induce robust feeding, there is little information about the patterns of feeding elicited by this peptide. To reveal these patterns, NPY (0, 8, 24, 78, 235 pmol/10 nl) was injected into the perifornical hypothalamus (PFH) of satiated adult male rats and their subsequent food intake was monitored every minute for 24 h. For comparison, feeding patterns were similarly observed following fasts of 0, 3, 6, 9, 12, and 24 h. The results demonstrated that NPY and food deprivation both produced dose- or deprivation-dependent increases in food intake that were most evident in the first 6 h. The increased intakes induced by NPY were characterized by combinations of increased meal size and frequency, with the predominant effects being increases in the size of and decreased latency to eat the first meal. Similarly, fasting progressively increased food intake by combinations of increased meal size and frequency, with the predominant effects being increases in the size of and decreased latency to eat the first meal. These similarities between NPY-induced and food deprivation-induced feeding are consistent with a stimulatory role for endogenous NPY in deprivation-induced feeding. These findings also suggest that NPY may increase eating by acting on mechanisms of both meal initiation and of meal termination.
虽然向下丘脑注射神经肽Y（NPY）会引发强烈的进食行为，但关于这种肽引发的进食模式的信息却很少。为了揭示这些模式，将NPY（0、8、24、78、235皮摩尔/10纳升）注射到饱腹的成年雄性大鼠的穹窿周下丘脑（PFH）中，并在24小时内每分钟监测它们随后的食物摄入量。为了进行比较，在禁食0、3、6、9、12和24小时后，同样观察进食模式。结果表明，NPY和食物剥夺均产生了剂量或剥夺依赖性的食物摄入量增加，这在前6小时最为明显。NPY诱导的摄入量增加的特征是进餐量和频率增加的组合，主要影响是第一餐的进餐量增加和进食潜伏期缩短。同样，禁食通过增加进餐量和频率的组合逐渐增加食物摄入量，主要影响是第一餐的进餐量增加和进食潜伏期缩短。NPY诱导的进食与食物剥夺诱导的进食之间的这些相似性与内源性NPY在剥夺诱导的进食中的刺激作用一致。这些发现还表明，NPY可能通过作用于进餐开始和结束机制来增加进食。
