Yoon Y D, Waring G O, Stulting R D, Edelhauser H F, Grossniklaus H E
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Cornea. 1998 Mar;17(2):180-4. doi: 10.1097/00003226-199803000-00011.
To study the histology and pattern of keratocyte repopulation of surgically removed human epikeratoplasty lenticules.
Removed epikeratoplasty lenticules and penetrating keratoplasty buttons that contained epikeratoplasty lenticules were evaluated for duration of epikeratoplasty, histologic and ultrastructural features, and average number of keratocytes per high-power microscopic field. The keratocyte density was compared with age-matched controls.
Fifteen epikeratoplasty specimens from eight penetrating keratoplasties and seven removed lenticules were reviewed. The indications for keratoplasty were myopia, keratoconus, and aphakia. The lenticules were in place for 7-120 months, and the keratocyte count ranged from 14 to 40 per high-power field. Keratocyte density increased to 30-40 per high-power field, similar to age-matched controls, at approximately 48 months postoperatively, similar to the density of the controls. Keratocytes appeared to have migrated from the periphery to the center of the lenticules.
Normal keratocyte density in epikeratoplasty lenticules is reached by approximately 48 months after surgery.
研究手术切除的人类表层角膜镜片术透镜的组织学及角膜细胞再增殖模式。
对切除的表层角膜镜片术透镜以及包含表层角膜镜片术透镜的穿透性角膜移植片进行评估，内容包括表层角膜镜片术的持续时间、组织学和超微结构特征以及每个高倍显微镜视野下角膜细胞的平均数量。将角膜细胞密度与年龄匹配的对照组进行比较。
回顾了来自8例穿透性角膜移植术的15个表层角膜镜片术标本以及7个切除的透镜。角膜移植术的适应证为近视、圆锥角膜和无晶状体眼。透镜在位时间为7至120个月，每个高倍视野下的角膜细胞计数范围为14至40个。术后约48个月时，角膜细胞密度增加至每个高倍视野30至40个，与年龄匹配的对照组相似。角膜细胞似乎已从透镜周边迁移至中心。
术后约48个月时，表层角膜镜片术透镜中的角膜细胞密度达到正常水平。
