慢性神经性疼痛患者能否通过急性给予NMDA受体拮抗剂金刚烷胺治愈？
Can patients with chronic neuropathic pain be cured by acute administration of the NMDA receptor antagonist amantadine?
作者信息
Eisenberg E, Pud D
机构信息
Pain Relief Unit, Rambam Medical Center, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa.
出版信息
Pain. 1998 Feb;74(2-3):337-9. doi: 10.1016/s0304-3959(97)00198-x.
PMID:9520249
Abstract
The treatment of neuropathic pain remains a challenge as it rarely leads to long-term relief of symptoms. We report three patients with chronic neuropathic pain, in whom acute administration of the N-methyl-D-aspartate (NMDA) receptor antagonist amantadine resulted in complete resolution of symptoms, presumably due to termination the central 'wind-up' phenomenon.
摘要
神经性疼痛的治疗仍然是一项挑战，因为它很少能带来症状的长期缓解。我们报告了三名慢性神经性疼痛患者，对他们急性给予N-甲基-D-天冬氨酸（NMDA）受体拮抗剂金刚烷胺后，症状完全缓解，推测这是由于终止了中枢性“wind-up”现象。
Zotero 插件