肽在II类主要组织相容性复合体限制性T细胞胸腺阳性选择中的作用。
The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells.
作者信息
Wang R, Nelson A, Kimachi K, Grey H M, Farr A G
机构信息
La Jolla Institute for Allergy and Immunology, Division of Immunochemistry, 10355 Science Center Drive, San Diego, CA 92121, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3804-9. doi: 10.1073/pnas.95.7.3804.
Abstract
A thymic epithelial cell line transfected with I-Ek was used in reaggregate cultures to study the role of peptides in positive selection of T cell receptor transgenic thymocytes. In this system, positive selection of CD4 SP cells occurred only after the addition of exogenous peptide. Analysis of antigen analogs indicated an inverse relationship between the antigenicity for peripheral T cells and the concentration of peptide required for positive selection. These data are most consistent with an avidity (rather than an affinity) model of positive selection, in which ligand density and the affinity of T cell receptor act in concert to determine the fate of developing thymocytes.
摘要
用转染了I-Ek的胸腺上皮细胞系进行重聚集培养，以研究肽在T细胞受体转基因胸腺细胞阳性选择中的作用。在该系统中，只有添加外源性肽后才会发生CD4单阳性细胞的阳性选择。对抗原类似物的分析表明，外周T细胞的抗原性与阳性选择所需的肽浓度之间呈反比关系。这些数据与阳性选择的亲和力（而非亲和力）模型最为一致，在该模型中，配体密度和T细胞受体的亲和力共同作用以决定发育中胸腺细胞的命运。
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本文引用的文献
1
Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells.由单一主要组织相容性复合体/肽配体进行的胸腺选择产生了半多样化的CD4+ T细胞库。
Immunity. 1997 Aug;7(2):209-19. doi: 10.1016/s1074-7613(00)80524-5.
2
Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice.H-2Ma0/0小鼠中CD4+ T细胞广泛谱系的选择。
Immunity. 1997 Aug;7(2):187-95. doi: 10.1016/s1074-7613(00)80522-1.
3
T cells can be activated by peptides that are unrelated in sequence to their selecting peptide.T细胞可被与其选择肽序列无关的肽激活。
Immunity. 1997 Aug;7(2):179-86. doi: 10.1016/s1074-7613(00)80521-x.
4
5
The responses of mature T cells are not necessarily antagonized by their positively selecting peptide.成熟T细胞的反应不一定会被其阳性选择肽所拮抗。
J Immunol. 1996 Sep 1;157(5):1827-31.
6
Mature T cell reactivity altered by peptide agonist that induces positive selection.肽激动剂诱导阳性选择改变成熟T细胞反应性。
J Exp Med. 1996 Mar 1;183(3):1093-104. doi: 10.1084/jem.183.3.1093.
7
Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus.肽有助于胸腺中CD8 + T细胞阳性选择的特异性。
Cell. 1993 Jun 4;73(5):1041-9. doi: 10.1016/0092-8674(93)90281-t.
8
Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.主要组织相容性复合体结合肽在胎儿胸腺器官培养中诱导CD8 + T细胞的阳性选择。
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