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1
The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells.肽在II类主要组织相容性复合体限制性T细胞胸腺阳性选择中的作用。
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3804-9. doi: 10.1073/pnas.95.7.3804.
2
A role for accessibility to self-peptide-self-MHC complexes in intrathymic negative selection.自身肽-自身MHC复合物的可及性在胸腺内阴性选择中的作用。
J Immunol. 2001 Apr 1;166(7):4429-37. doi: 10.4049/jimmunol.166.7.4429.
3
Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture.胎儿胸腺器官培养中II类主要组织相容性复合体限制的胸腺细胞的配体特异性选择。
J Immunol. 2000 Jun 1;164(11):5675-82. doi: 10.4049/jimmunol.164.11.5675.
4
In vitro positive selection and anergy induction of class II-restricted TCR transgenic thymocytes by a cortical thymic epithelial cell line.通过一种皮质胸腺上皮细胞系对II类限制性TCR转基因胸腺细胞进行体外阳性选择和无能诱导。
Int Immunol. 1998 Sep;10(9):1335-46. doi: 10.1093/intimm/10.9.1335.
5
TCR signaling for initiation and completion of thymocyte positive selection has distinct requirements for ligand quality and presenting cell type.胸腺细胞阳性选择启动和完成过程中的TCR信号传导对配体质量和呈递细胞类型有不同的要求。
J Immunol. 2000 Sep 15;165(6):3015-22. doi: 10.4049/jimmunol.165.6.3015.
6
Evidence for a differential avidity model of T cell selection in the thymus.胸腺中T细胞选择的差异亲和力模型的证据。
Cell. 1994 Feb 25;76(4):651-63. doi: 10.1016/0092-8674(94)90505-3.
7
Human CD4 expression at the late single-positive stage of thymic development supports T cell maturation and peripheral export in CD4-deficient mice.人类CD4在胸腺发育晚期单阳性阶段的表达支持CD4缺陷小鼠的T细胞成熟和外周输出。
J Immunol. 2002 Oct 15;169(8):4347-53. doi: 10.4049/jimmunol.169.8.4347.
8
Replacement of N-glycosylation sites on the MHC class II E alpha chain. Effect on thymic selection and peripheral T cell activation.MHC II类Eα链上N-糖基化位点的替换。对胸腺选择和外周T细胞活化的影响。
J Immunol. 1995 May 15;154(10):5023-9.
9
Peptide specificity of thymic selection of CD4+CD25+ T cells.CD4+CD25+ T细胞胸腺选择的肽特异性
J Immunol. 2002 Jan 15;168(2):613-20. doi: 10.4049/jimmunol.168.2.613.
10
Positive and negative CD4+ thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus.单个II类主要组织相容性复合体/肽配体通过其在胸腺中的表达水平影响CD4+胸腺细胞的阳性和阴性选择。
Immunity. 1997 Apr;6(4):401-10. doi: 10.1016/s1074-7613(00)80283-6.

引用本文的文献

1
Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression.RB 家族的失活通过直接控制 Foxn1 的表达来防止胸腺萎缩并促进胸腺功能。
J Exp Med. 2013 Jun 3;210(6):1087-97. doi: 10.1084/jem.20121716. Epub 2013 May 13.
2
An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells.一种内源性肽可正向选择并增强外周CD4+ T细胞的活化和存活。
Nat Immunol. 2009 Nov;10(11):1155-61. doi: 10.1038/ni.1796. Epub 2009 Oct 4.
3
Functional reprogramming of the primary immune response by T cell receptor antagonism.通过T细胞受体拮抗作用对初次免疫反应进行功能重编程。
J Exp Med. 2004 Dec 6;200(11):1371-82. doi: 10.1084/jem.20041226. Epub 2004 Nov 22.
4
Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity.双阳性胸腺细胞与皮质上皮细胞呈递的高亲和力配体之间的相互作用产生具有T细胞调节活性的双阴性胸腺细胞。
Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2181-6. doi: 10.1073/pnas.042692799. Epub 2002 Feb 12.
5
Positive selection of CD4(+) T cells is induced in vivo by agonist and inhibited by antagonist peptides.激动剂可在体内诱导CD4(+) T细胞的阳性选择，而拮抗剂肽则可抑制这种选择。
J Exp Med. 2001 Aug 20;194(4):407-16. doi: 10.1084/jem.194.4.407.
6
Immunological self/nonself discrimination: integration of self vs nonself during cognate T cell interactions with antigen-presenting cells.免疫自我/非自我识别：在同源T细胞与抗原呈递细胞相互作用过程中自我与非自我的整合。
Immunol Res. 1999;19(1):65-87. doi: 10.1007/BF02786477.

本文引用的文献

1
Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells.由单一主要组织相容性复合体/肽配体进行的胸腺选择产生了半多样化的CD4+ T细胞库。
Immunity. 1997 Aug;7(2):209-19. doi: 10.1016/s1074-7613(00)80524-5.
2
Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice.H-2Ma0/0小鼠中CD4+ T细胞广泛谱系的选择。
Immunity. 1997 Aug;7(2):187-95. doi: 10.1016/s1074-7613(00)80522-1.
3
T cells can be activated by peptides that are unrelated in sequence to their selecting peptide.T细胞可被与其选择肽序列无关的肽激活。
Immunity. 1997 Aug;7(2):179-86. doi: 10.1016/s1074-7613(00)80521-x.
4
Differential T cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses.拮抗剂肽 - 主要组织相容性复合体复合物诱导的差异性T细胞信号传导及相关表型反应。
J Immunol. 1997 Mar 1;158(5):2057-64.
5
The responses of mature T cells are not necessarily antagonized by their positively selecting peptide.成熟T细胞的反应不一定会被其阳性选择肽所拮抗。
J Immunol. 1996 Sep 1;157(5):1827-31.
6
Mature T cell reactivity altered by peptide agonist that induces positive selection.肽激动剂诱导阳性选择改变成熟T细胞反应性。
J Exp Med. 1996 Mar 1;183(3):1093-104. doi: 10.1084/jem.183.3.1093.
7
Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus.肽有助于胸腺中CD8 + T细胞阳性选择的特异性。
Cell. 1993 Jun 4;73(5):1041-9. doi: 10.1016/0092-8674(93)90281-t.
8
Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.主要组织相容性复合体结合肽在胎儿胸腺器官培养中诱导CD8 + T细胞的阳性选择。
J Exp Med. 1993 May 1;177(5):1469-73. doi: 10.1084/jem.177.5.1469.
9
MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus.MHC II类阳性上皮细胞和间充质细胞都是胸腺中T细胞发育所必需的。
Nature. 1993 Mar 4;362(6415):70-3. doi: 10.1038/362070a0.
10
T cell receptor antagonist peptides induce positive selection.T细胞受体拮抗剂肽诱导阳性选择。
Cell. 1994 Jan 14;76(1):17-27. doi: 10.1016/0092-8674(94)90169-4.

肽在II类主要组织相容性复合体限制性T细胞胸腺阳性选择中的作用。

The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells.

作者信息

Wang R, Nelson A, Kimachi K, Grey H M, Farr A G

机构信息

La Jolla Institute for Allergy and Immunology, Division of Immunochemistry, 10355 Science Center Drive, San Diego, CA 92121, USA.

出版信息

Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3804-9. doi: 10.1073/pnas.95.7.3804.

DOI:10.1073/pnas.95.7.3804
PMID:9520448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC19918/
Abstract

A thymic epithelial cell line transfected with I-Ek was used in reaggregate cultures to study the role of peptides in positive selection of T cell receptor transgenic thymocytes. In this system, positive selection of CD4 SP cells occurred only after the addition of exogenous peptide. Analysis of antigen analogs indicated an inverse relationship between the antigenicity for peripheral T cells and the concentration of peptide required for positive selection. These data are most consistent with an avidity (rather than an affinity) model of positive selection, in which ligand density and the affinity of T cell receptor act in concert to determine the fate of developing thymocytes.

摘要

用转染了I-Ek的胸腺上皮细胞系进行重聚集培养，以研究肽在T细胞受体转基因胸腺细胞阳性选择中的作用。在该系统中，只有添加外源性肽后才会发生CD4单阳性细胞的阳性选择。对抗原类似物的分析表明，外周T细胞的抗原性与阳性选择所需的肽浓度之间呈反比关系。这些数据与阳性选择的亲和力（而非亲和力）模型最为一致，在该模型中，配体密度和T细胞受体的亲和力共同作用以决定发育中胸腺细胞的命运。