Andrews B, Measday V
Department of Molecular and Medical Genetics, University of Toronto, Canada.
Trends Genet. 1998 Feb;14(2):66-72. doi: 10.1016/s0168-9525(97)01322-x.
Cyclins are highly conserved proteins that activate cyclin-dependent kinases (CDKs) to regulate the cell cycle, transcription and other cellular processes. The completion of the genome sequence of the budding yeast Saccharomyces cerevisiae allows an appraisal of the functions of the entire complement of cyclins in a eukaryotic organism. The cyclin family of budding yeast is reviewed from a functional perspective with an emphasis on what genetic and biochemical experiments have revealed about cyclin-CDK substrates.
细胞周期蛋白是高度保守的蛋白质，可激活细胞周期蛋白依赖性激酶（CDK）以调节细胞周期、转录及其他细胞过程。酿酒酵母基因组序列的完成，使得对真核生物中细胞周期蛋白全家族功能的评估成为可能。本文从功能角度对酿酒酵母的细胞周期蛋白家族进行综述，重点阐述遗传和生化实验在细胞周期蛋白 - CDK底物方面的研究成果。
