Cossman J, Messineo C, Bagg A
Georgetown University School of Medicine, Washington, D.C., USA.
Lab Invest. 1998 Mar;78(3):229-35.
In contrast to the non-Hodgkin's lymphomas, little is known regarding the origin, genetics, and function of the Reed-Sternberg cell of Hodgkin's disease. Unlike other cancers, the neoplastic cell of Hodgkin's disease, the Reed-Sternberg cell, is vastly outnumbered by a surrounding intense inflammatory infiltrate. How this rare neoplastic cell originates, persists, and disseminates in a presumably hostile cellular environment has remained a mystery. Understanding the biology of the Reed-Sternberg cell has been impeded by the rarity of the cell in tumor tissue. Herein, we describe how the application of single-cell genetic analysis has revealed a clonal and, possibly, germinal center B-cell origin of the Reed-Sternberg cell. By phenotype and function, Reed-Sternberg cells are highly interactive with their cellular microenvironment through cell-cell adhesion, expression of members of the tumor necrosis factor receptor superfamily, and elaboration of cytokines. Perhaps by their mimicry of immune system cells with antigen-presenting function, Reed-Sternberg cells mediate the unusual clinical and pathologic features of Hodgkin's disease: intense tissue inflammatory infiltrate, fibrosis, and constitutional symptoms.
与非霍奇金淋巴瘤不同，关于霍奇金病里德-斯腾伯格细胞的起源、遗传学和功能，人们了解甚少。与其他癌症不同，霍奇金病的肿瘤细胞，即里德-斯腾伯格细胞，在数量上远远少于周围强烈的炎性浸润细胞。这种罕见的肿瘤细胞如何在一个可能充满敌意的细胞环境中起源、持续存在并扩散，一直是个谜。肿瘤组织中里德-斯腾伯格细胞的稀缺阻碍了对其生物学特性的理解。在此，我们描述了单细胞基因分析的应用如何揭示了里德-斯腾伯格细胞的克隆起源，并且可能是生发中心B细胞起源。从表型和功能来看，里德-斯腾伯格细胞通过细胞间黏附、肿瘤坏死因子受体超家族成员的表达以及细胞因子的分泌，与其细胞微环境高度相互作用。也许通过模仿具有抗原呈递功能的免疫系统细胞，里德-斯腾伯格细胞介导了霍奇金病不同寻常的临床和病理特征：强烈的组织炎性浸润、纤维化和全身症状。
