Kawano N
Department of Neurosurgery, Kitasato University School of Medicine, Kanagawa, Japan.
Clin Neuropathol. 1992 Nov-Dec;11(6):323-8.
Fourteen cases of pleomorphic xanthoastrocytoma (PXA) occurring in Japan were investigated to evaluate its various pathological features. The patients were generally young (average: 19 years), the tumor was superficially located and CT revealed well circumscribed contrast enhancing mass which was often accompanied by a cyst. Histopathological study revealed that the PXA is a pleomorphic and frequently desmoplastic astrocytic tumor characterized by chronic degenerative changes including lipidization of tumor cells. The desmoplasia was assumed to secondary proliferation of meningeal fibroblasts. Although the general consensus is that pial astrocytes are the most likely origin of PXA, "ordinary" astrocytoma may well develop into PXA by invading overlying meninges and inducing desmoplasia.
对日本发生的14例多形性黄色星形细胞瘤（PXA）进行了研究，以评估其各种病理特征。患者通常较为年轻（平均19岁），肿瘤位于浅表，CT显示边界清晰的强化肿块，常伴有囊肿。组织病理学研究表明，PXA是一种多形性且常为促纤维增生性的星形细胞瘤，其特征为包括肿瘤细胞脂质化在内的慢性退行性改变。促纤维增生被认为是脑膜成纤维细胞的继发性增殖。尽管普遍认为软脑膜星形细胞最可能是PXA的起源，但“普通”星形细胞瘤很可能通过侵犯上方的脑膜并诱导促纤维增生而发展为PXA。
