Inoue M, Kobayashi S, Matsuura A, Hamajima N, Tajima K, Tominaga S
Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan.
Cancer Epidemiol Biomarkers Prev. 1998 Mar;7(3):261-3.
Serum pepsinogen I and II levels have recently become popular as indicators of atrophic gastritis in epidemiological studies. Previous studies show a significant association between serum pepsinogen levels and endoscopically diagnosed atrophic gastritis. This study assesses the level of agreement between the degree of atrophic gastritis as assessed by endoscopic examination and by serum pepsinogen assays. Study subjects were 200 outpatients at Aichi Cancer Center Hospital, Nagoya, Japan, who were endoscoped between February and August 1995. Agreement of the degree of atrophic gastritis was assessed by endoscopic examination and by serum pepsinogen levels. Agreement in assessing the extent of atrophic gastritis between the two methods was 57%, and the presence of atrophic gastritis was 79%. Serum pepsinogen assays identify the majority of patients with atrophic gastritis, although they are less useful in assessing the degree of atrophy in detail.
血清胃蛋白酶原I和II水平最近在流行病学研究中作为萎缩性胃炎的指标而受到欢迎。先前的研究表明血清胃蛋白酶原水平与内镜诊断的萎缩性胃炎之间存在显著关联。本研究评估了通过内镜检查和血清胃蛋白酶原检测评估的萎缩性胃炎程度之间的一致性水平。研究对象为日本名古屋爱知癌症中心医院的200名门诊患者，他们于1995年2月至8月期间接受了内镜检查。通过内镜检查和血清胃蛋白酶原水平评估萎缩性胃炎的程度。两种方法在评估萎缩性胃炎范围方面的一致性为57%，在萎缩性胃炎的存在方面为79%。血清胃蛋白酶原检测可识别出大多数萎缩性胃炎患者，尽管在详细评估萎缩程度方面作用较小。
