用IKH-4（一种对小汗腺具有特异性的单克隆抗体）对小汗腺和大汗腺肿瘤以及转移性腺癌进行染色。
Staining of eccrine and apocrine neoplasms and metastatic adenocarcinoma with IKH-4, a monoclonal antibody specific for the eccrine gland.
作者信息
Ishihara M, Mehregan D R, Hashimoto K, Yotsumoto S, Toi Y, Pietruk T, Mehregan A H, Mehregan D A
机构信息
Wayne State University School of Medicine, Detroit, Michigan, USA.
出版信息
J Cutan Pathol. 1998 Feb;25(2):100-5. doi: 10.1111/j.1600-0560.1998.tb01697.x.
The histogenesis of apocrine and eccrine neoplasms has always interested dermatopathologists. In addition, the histologic differential diagnosis of eccrine carcinoma from metastatic adenocarcinoma is of practical importance. We describe a novel monoclonal antibody IKH-4 which stains the eccrine secretory coil, but not the apocrine secretory segment. Positive staining was observed in eccrine hidradenoma, eccrine poroma, eccrine spiradenoma, papillary eccrine adenoma, eccrine hidrocystoma, syringoma, eccrine carcinoma, and in 1 case of syringocystadenoma papilliferum. Negative staining was observed in apocrine adenocarcinoma, hidradenoma papilliferum, erosive adenomatosis of the nipple, and primary and metastatic adenocarcinomas. IKH-4 antibody was useful in differentiating eccrine from apocrine neoplasms and in differentiating eccrine carcinoma from metastatic adenocarcinomas.
大汗腺和小汗腺肿瘤的组织发生一直是皮肤病理学家感兴趣的问题。此外，小汗腺癌与转移性腺癌的组织学鉴别诊断具有实际重要性。我们描述了一种新型单克隆抗体IKH - 4，它能对小汗腺分泌蟠管染色，但不能对大汗腺分泌段染色。在小汗腺汗腺瘤、小汗腺导管瘤、小汗腺螺旋腺瘤、乳头状小汗腺腺瘤、小汗腺囊瘤、汗管瘤、小汗腺癌以及1例乳头乳晕糜烂性腺瘤病中观察到阳性染色。在大汗腺癌、乳头状汗腺瘤、乳头糜烂性腺瘤病以及原发性和转移性腺癌中观察到阴性染色。IKH - 4抗体有助于鉴别大汗腺肿瘤与小汗腺肿瘤，以及鉴别小汗腺癌与转移性腺癌。
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