Kawakubo Y, Shinagawa H, Akamatsu M, Iizuka M, Tsutsumi Y, Ohkido M
Dermatologische Abteilung, Tokai Universität, Kanagawa, Japan.
Hautarzt. 1998 Jan;49(1):36-40. doi: 10.1007/s001050050698.
A 48-year-old woman developed granulomatous slack skin (GSS), one of the special forms of cutaneous T-cell lymphoma. The lesional skin slack with an atrophic, poikilodermic surface and granulomatous induration. Histopathological findings included epidermotropism, diffuse lymphoid cell infiltration and foreign body giant cells as well as granulomatous reactions from superficial to deep dermis, including part the subcutis. The diagnosis was established by positive results for rearrangement of the T-cell receptor gene. The therapeutic possibilities, especially with corticosteroids and monitoring the disease course by following serum angiotensin converting enzyme activity are discussed.
一名48岁女性患上了肉芽肿性皮肤松弛症（GSS），这是皮肤T细胞淋巴瘤的一种特殊形式。皮损皮肤松弛，表面萎缩、斑驳，有肉芽肿性硬结。组织病理学检查结果包括亲表皮现象、弥漫性淋巴细胞浸润、异物巨细胞以及从浅表真皮至深部真皮（包括部分皮下组织）的肉芽肿反应。通过T细胞受体基因重排的阳性结果确诊。文中讨论了治疗的可能性，尤其是使用皮质类固醇治疗以及通过监测血清血管紧张素转换酶活性来监测疾病进程。
